54810-54-7Relevant academic research and scientific papers
Magnetic Fe3O4-BF3: Highly efficient Lewis acid catalyst for the synthesis of α-aminonitriles
Shekouhy, Mohsen,Moaddeli, Ali,Khalafi-Nezhad, Ali
, p. 3805 - 3827 (2016/04/05)
Fe3O4 magnetic nanoparticle-supported BF3 was prepared as a new magnetically separable Lewis acid catalyst and successfully used for the one-pot synthesis of α-aminonitriles. A broad range of substrates including the aromatic and heteroaromatic aldehydes, cyclic ketones (cyclopentanone, cyclohexanone and cycloheptanone), aryl-alkyl ketones, diaryl ketones and tetralones, isatin derivatives and acenaphthenequinone were condensed with amines (aliphatic and aromatic) and trimethylsilyl cyanide. All reactions were completed in short times and products were obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency. Finally, α-aminonitrile containing adenine was successfully synthesized.
Lithium tetrafluoroborate-catalyzed solventless synthesis of α-aminonitriles
Desai, Uday V.,Mitragotri, Satish D.,Thopate, Takaram S.,Pore, Dattaprasad M.,Wadgaonkar, Prakash P.
, p. 759 - 762 (2008/02/09)
Lithium tetrafluoroborate-catalyzed one-pot, highly efficient, and solvent-free protocol has been developed for the synthesis of α-aminonitriles from aldehydes/ketones, amines, and trimethylsilyl cyanide.
(Bromodimethyl)sulfonium bromide catalyzed one-pot synthesis of α-aminonitriles
Das, Biswanath,Ramu,Ravikanth,Reddy, K. Ravinder
, p. 1419 - 1422 (2007/10/03)
A novel, simple and efficient one-pot synthesis of α-aminonitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of (bromodimethyl)sulfonium bromide as a catalyst at room temperature. The products were obtained in high yields and in short reaction times. Georg Thieme Verlag Stuttgart.
Indium trichloride catalyzed one-step synthesis of α-amino nitriles by a three-component condensation of carbonyl compounds, amines and potassium cyanide
Ranu, Brindaban C,Dey, Suvendu S,Hajra, Alakananda
, p. 2529 - 2532 (2007/10/03)
A simple and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes or ketones, amines and potassium cyanide in THF in presence of a catalytic amount of indium trichloride.
