54812-04-3

Upstream product

• 58-27-5 menadione 
• 105398-69-4 Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 110-82-7 cyclohexane 
• 98-89-5 Cyclohexanecarboxylic acid 
• 614-45-9 tert-Butyl peroxybenzoate 
• 34987-31-0 2‐cyclohexylnaphthalene‐1,4‐dione 
• 75-65-0 tert-butyl alcohol 

Relevant academic research and scientific papers

Iron-Catalyzed Radical Methylation of Activated Alkenes with tert -Butanol as the Methyl Source

A free-radical-initiated methylation/addition/cyclization of N -arylacrylamides and a methylation/addition/elimination of quinines have been developed in which t -BuOH is used as a methyl source. These reactions provide effective and selective methods for the synthesis of various methylated oxindoles and quinones in moderate to good yields.

Functionalization of saturated hydrocarbons in Gif-type systems using 2-methyl-1,4-naphthoquinone

The reaction between cyclohexane and 2-methyl-1,4-naphthoquinone 1 using hydrogen peroxide in the Fe(II)-Fe(IV) manifold gave the adduct 2 in good yield. The same reaction was carried out with the Fe(III)-H2O2 system and gave also so

Visible light-promoted Selectfluor-mediated quinone functionalization with unactivated Csp3-H components

A visible light-promoted metal-free cross-dehydrogenative-coupling (CDC) method for the alkylation of 1,4-naphthoquinones is reported using Selectfluor as a hydrogen atom transfer (HAT) agent. This protocol is suitable for a variety of 1,4-naphthoquinones and Csp3-H compounds and it facilitates the formation of pharmaceutically important quinone scaffolds under mild conditions. Using this methodology, the antimalarial drug, parvaquone, was synthesized in a single step.

Bismuth-catalyzed methylation and alkylation of quinone derivatives with tert-butyl peroxybenzoate as an oxidant

A bismuth-catalyzed methylation of quinones in the presence of tert-butyl peroxybenzoate (TBPB) was developed via a radical reaction mechanism. Particularly, TBPB was used not only as an efficient oxidant, but also as a green methyl source in such transformation. Moreover, this method could also be efficiently extended to the alkylation of quinones. This reaction tolerated a series of functional groups and prepared a series of derivatives of vitamin K3 and benzoquinone. Notably, antimalarial parvaquone was synthesized by the reaction.

Naphthoquinone Derivatives, Benzoquinone Derivatives, and Anthracenedione Derivatives, Their Use and Novel Method for Preparation

The present invention relates to: a novel manufacturing method of quinone derivatives or anthracenedione derivatives by a copper-catalyzed cross-dehydrogenation coupling reaction of naphthoquinone, benzoquinone or anthracenedione compounds with various cycloalkanes; naphthoquinone derivatives, benzoquinone derivatives and anthracenedione derivatives; and uses thereof. According to the novel manufacturing method of the present invention, since the naphthoquinone derivatives, benzoquinone derivatives or anthracenedione derivatives can be prepared in one step, manufacturing efficiency is improved and cost and time can be saved, and the derivatives according to the present invention can be variously used as an animal medicine.COPYRIGHT KIPO 2019

Metal-, Photocatalyst-, and Light-Free, Late-Stage C-H Alkylation of Heteroarenes and 1,4-Quinones Using Carboxylic Acids

Contrary to the accepted convention, this work shows that Minisci-type C-H alkylation does not require any metal, photocatalyst, light, or prefunctionalization of the readily available and inexpensive carboxylic acids to proceed well under mild conditions. These mild conditions can be utilized for late-stage alkylations of complex molecules, including pharmaceutical compounds and light-sensitive compounds which degrade under photocatalytic conditions.

THE INVENTION OF RADICAL REACTIONS. PART XIX. THE SYNTHESIS OF VERY HINDERED QUINONES

On photolysis with tungsten light, the acyl derivatives of N-hydroxy-2-thiopyridone afford carbon radicals which readily add to quinones.In the case of benzoquinone radical addition is followed by 2-thiopyridyl transfer to afford adducts of type 4.Two different procedures were developed for the conversion of type 4 compounds into hindered quinones of type 7.