54820-20-1Relevant academic research and scientific papers
Exploration of fluoral hydrazones derived from carbohydrazides for the synthesis of trifluoromethylated heterocycles
Mloston, Grzegorz,Urbaniak, Katarzyna,Jacaszek, Natalia,Linden, Anthony,Heimgartner, Heinz
, p. 387 - 401 (2014)
The reaction of fluoral hydrate with carbohydrazides in methanol in the presence of molecular sieves (4 A) gave the desired N-acylated fluoral hydrazones (3a-f) in fair yields. Treatment of the latter with mercaptoacetic acid in benzene led to the corresponding 2-trifluoromethyl-1,3-thiazolidinone derivatives (4a-f), whereas the reaction with acetic anhydride gave 3-acetyl-2,3-dihydro-2-trifluoromethyl-1,3,4-oxadiazoles (5a-f). The structures of each type of product have been established by X-ray crystallography.
