54838-22-1Relevant academic research and scientific papers
Organophosphine-catalyzed intramolecular hydroacylation of activated alkynes
Mondal, Atanu,Hazra, Raju,Grover, Jagdeep,Raghu, Moluguri,Ramasastry
, p. 2748 - 2753 (2018/04/14)
We present the details of an organophosphine-catalyzed Morita-Baylis-Hillman-type reaction of activated alkynes. The outcome is an intramolecular hydroacylation of α,β-ynones leading to the formation of 1,3-cyclopenta-, cyclohepta-, and cyclooctadione-fused arenes and heteroarenes. In addition, during the course of the investigation, a phosphine-catalyzed intramolecular aldol reaction of keto-ynones via δ′[C(sp3)-H]-functionalization was discovered, and a new annulation event comprising of a ω′[C(sp3)-H]-functionalization of α,β-ynones was also uncovered. The mechanisms governing these processes have been thoroughly elucidated.
