548458-96-4Relevant academic research and scientific papers
Synthesis of dopamine transporter selective 3-{2-(diarylmethoxyethylidene)}-8-alkylaryl-8-azabicyclo[3.2.1]octanes
Bradley, Amy L.,Izenwasser, Sari,Wade, Dean,Cararas, Shaine,Trudell, Mark L.
, p. 629 - 632 (2007/10/03)
A series of 3-{2-(diarylmethoxyethylidene)}-8-alkylaryl-8-azabicyclo[3.2.1]octanes was synthesized and the binding affinities of the compounds were determined at the dopamine and serotonin transporters. The 8-phenylpropyl analogues 8a (Ki=4.1 n
Synthesis and biological evaluation of tropane-like 1-{2-[bis(4-fluorophenyl)methoxy]ethyl})-4-(3-phenylpropyl)piperazine (GBR 12909) analogues
Zhang,Joseph,Bowen,Flippen-Anderson,Dersch,Rothman,Jacobson,Rice
, p. 3937 - 3945 (2007/10/03)
We have prepared azabicyclo[3.2.1] derivatives (C-3-substituted tropanes) that bind with high affinity to the dopamine transporter and inhibit dopamine reuptake. Within the series, 3-{(2-[bis-(4-fluorophenyl)methoxy] ethylidene}-8-methyl-8-azabicyclo[3.2.
