548490-52-4Relevant academic research and scientific papers
Fast, solid-phase synthesis of chiral peptide nucleic acids with a high optical purity by a submonomeric strategy
Sforza, Stefano,Tedeschi, Tullia,Corradini, Roberto,Ciavardelli, Domenico,Dossena, Arnaldo,Marchelli, Rosangela
, p. 1056 - 1063 (2003)
The solid-phase synthesis of chiral peptide nucleic acids (PNAs) usually results in partial epimerization of the products, since the α-nitrogen atom of the amino acid is involved in an amidic bond. It is also time-consuming, since all the chiral monomers
