54852-68-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-4-chloro-6-bromophenol is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Methyl-4-chloro-6-bromophenol serves as an intermediate in the production of various agrochemicals, including pesticides and herbicides. Its properties contribute to the effectiveness of these products in controlling pests and weeds.
Used in Dye and Perfume Industry:
2-Methyl-4-chloro-6-bromophenol is utilized as a chemical intermediate in the manufacturing of dyes and perfumes. Its strong odor and chemical properties make it a valuable component in creating a wide range of colorants and fragrances.

Upstream product

• 1570-64-5 2-methyl-4-chlorophenol 
• 2446-83-5 di-isopropyl azodicarboxylate 
• 1972-28-7 diethylazodicarboxylate 

Downstream Products

• 869085-32-5 2-bromo-4-chloro-6-methylphenyl 2-propenyl ether 

Relevant academic research and scientific papers

UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF

Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.

Poly(4-vinylpyridinium bromochromate): An efficient reagent for bromination of aromatic compounds

A simple and efficient method for the bromination of various aromatic compounds by using poly(4-vinylpyridinium bromochromate) is reported. This method has several advantages such as good selectivity between ortho and para positions of aromatic compounds, simple workup, short reaction times, and high yields of the products.

Regioselective bromination of activated aromatic substrates with a ZrBr4/diazene mixture

A regioselective method for the bromination of phenols, ethers and anilines using a ZrBr4/diazene mixture is described. The reaction takes place under mild reaction conditions and the bromine atom adds first at the para unsubstituted position with respect to the OH, OR or NR2 group of the activated aromatic substrate. Less reactive compounds such as toluene, phenyl acetate, benzonitrile and trifluoromethylbenzene remain intact under the same conditions.

Intramolecular carbolithiation of allyl o-lithioaryl ethers: A new enantioselective synthesis of functionalized 2,3-dihydrobenzofurans

A new and easy method for the diastereoselective synthesis of 3-functionalized 2,3-dihydrobenzofuran derivatives from allyl 2-bromoaryl ethers is described. The key step of this transformation involves an intramolecular carbolithiation reaction of allyl 2-lithioaryl ethers. The substituents in both the allyl and the aryl moieties play an important and decisive role in stopping the reaction at the benzofuran thus avoiding a γ-elimination reaction. Finally, this process is amenable to the synthesis of enantiomerically enriched compounds by using ( - )-sparteine as a chiral inductor.

Solid state nuclear bromination with N-bromosuccinimide. Part 1. Experimental and theoretical studies on some substituted aniline, phenol and nitro aromatic compounds

Solid state bromination of a number of substituted phenol, aniline and nitro aromatic compounds with N-bromosuccinimide yields exclusively the nuclear brominated products. Reactivity in the solid state depends on the reaction time, temperature and nature of the substituent on the substrate. The reaction apparently proceeds by an electrophilic aromatic substitution pathway. Molecular orbital and reaction free energy calculations also support such a view. Thermal analysis and video microscopic observation reveal the nature of the solid state reaction. Crystallinity is required for the reactivity and product selectivity. Product yield decreases with loss of selectivity when the reaction is carried out in a melt or in solution. Unlike the topochemical solid state reactions wherein molecular packing is more important than the intrinsic reactivity, these reactions demonstrate the importance of both these factors.