548762-59-0

Basic information

• Product Name: (2S,5R)-1-methoxycarbonyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine
• Synonyms: (2S,5R)-1-methoxycarbonyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine
• CAS NO: 548762-59-0
• Molecular Weight: 306.362
• Mol File: 548762-59-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,5R)-1-methoxycarbonyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-1-methoxycarbonyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine(548762-59-0)
• EPA Substance Registry System: (2S,5R)-1-methoxycarbonyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine(548762-59-0)

Safety Data

• Hazardous Substances Data: 548762-59-0(Hazardous Substances Data)

Upstream product

• 79-22-1 methyl chloroformate 
• 548762-58-9 (2S,5R)-1-allyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine 
• 2815-34-1 2,5-dimethyl-piperazine 
• 155836-79-6 (+)-(2S,5R)-1-allyl-2,5-dimethylpiperazine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 155836-78-5 (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine 
• 548762-61-4 (2S,5R)-1-methoxycarbonyl-2,5-dimethylpiperazine 

Relevant articles and documents

Enantioconvergent synthesis of (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine, an intermediate to δ-opioid receptor ligands

A convenient, high-yield enantioconvergent synthesis of (-)-1-allyl-(2S,5R)-dimethylpiperazine from trans-2,5-dimethylpiperazine has been developed. This compound is an important intermediate in the synthesis of Δ-opioid receptor ligands. The process allows for the laboratory preparation of 100 g quantities of this enantiomerically pure diamine without chromatography. The key steps in the sequence were an efficient optical resolution using relatively inexpensive resolving agents, followed by interconversion of the unwanted (+)-enantiomer into the desired (-)-enantiomer.