54879-74-2

Usage

General Description

2,2-DIMETHOXY-N-(PHENYLMETHYLENE)-1-ETHANAMINE is a chemical compound with a molecular formula C11H15NO2. It is a derivative of 2-dimethoxyaminoethylamine and is commonly used as a reagent in organic synthesis processes. 2,2-DIMETHOXY-N-(PHENYLMETHYLENE)-1-ETHANAMINE is known for its applications in the production of various pharmaceutical and agrochemical products. It has also been studied for its potential use in the treatment of neurological disorders and as a precursor in the synthesis of other complex organic molecules. Additionally, 2,2-DIMETHOXY-N-(PHENYLMETHYLENE)-1-ETHANAMINE is considered to be a useful building block in the development of new chemical compounds for industrial and research purposes.

Upstream product

• 100-52-7 benzaldehyde 
• 22483-09-6 2,2-dimethoxyethylamine 

Downstream Products

• 54879-88-8 N-benzyl-2,2-dimethoxyethylamine 
• 166947-03-1 benzyl benzyl(2-oxoethyl)carbamate 
• 307002-13-7 benzyl (benzyl)(2,2-dimethoxyethyl)carbamate 
• 307002-62-6 benzyl (benzyl){2-[2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl]-2-(1H-indol-3-yl)ethyl}carbamate 
• 307002-18-2 ethyl hydrogen 2-{2-[(benzyl)(benzyloxycarbonyl)amino]-1-(1H-indol-3-yl)ethyl}malonate 
• 307002-19-3 ethyl 4-[(benzyl)(benzyloxycarbonyl)amino]-2-[(benzyloxycarbonyl)amino]-3-(1H-indol-3-yl)butyrate 
• 23269-10-5 1-benzyl-1H-imidazole-2-thione 
• 84307-79-9 1-(2,2-Dimethoxy-ethyl)-2-phenyl-2,3-dihydro-1H-pyridin-4-one 
• 1456807-26-3 4-benzyl-6-methoxymorpholine-2-carbaldehyde 
• 1456807-25-2 (4-benzyl-6-methoxymorpholin-2-yl)methanol 
• 1456807-23-0 5-benzyl-10,10-diisopropyl-3-methoxy-11-methyl-2,9-dioxa-5-aza-10-siladodecan-7-ol 
• 1456807-35-4 1-(4-benzyl-6-methoxymorpholin-2-yl)ethanone 
• 1456807-34-3 1-(4-benzyl-6-methoxymorpholin-2-yl)ethanol 
• 1344688-58-9 C₁₈H₁₃NO₄ 

Relevant academic research and scientific papers

Six-Step Gram-Scale Synthesis of the Human Immunodeficiency Virus Integrase Inhibitor Dolutegravir Sodium

A short and practical synthesis for preparing the active pharmaceutical ingredient dolutegravir sodium was developed. The convergent strategy starts from (R)-3-amino-1-butanol and establishes the BC ring system in a 76% isolated yield over four steps. Ring A was constructed by a one-pot 1,4-addition to diethyl-(2E/Z)-2-(ethoxymethylidene)-3-oxobutandioate and subsequent MgBr2·OEt2-mediated regioselective cyclization. Amide formation with 2,4-difluorobenzylamine was either performed from the free carboxylic acid or through aminolysis of the corresponding ethyl ester. Final salt formation afforded dolutegravir sodium in a 48-51% isolated yield (HPLC purity of 99.7-99.9%) over six linear steps.

Flexible access to conformationally-locked bicyclic morpholines

A preparatively accessible route to a series of conformationally-locked bicyclic morpholines has been developed. This flexible approach allows for diversification in order for a small array of lead-like scaffolds to be synthesised from readily available k

Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors

Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7- dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this class o

A convenient synthesis of indole-substituted 2-pyrrolidones and their cyclized derivatives

Condensation between indole, Meldrum's acid, and benzyloxycarbonylacetaldehyde or aminoacetaldehyde derivatives yielded trimolecular adducts 7a-c. The latter were cyclized to indole-substituted 2-pyrrolidones 15a-b or 3-aminopyrrolid-2-ones 18a-b, dependi