54879-85-5Relevant academic research and scientific papers
Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction
Shi, Zeyu,Xiao, Qiong,Yin, Dali
supporting information, p. 729 - 732 (2019/10/02)
A versatile and efficient telescoped reaction sequence for the synthesis of tetrahydroisoquinolines (THIQs) is reported that uses TiCl4 to promote cyclization of a benzylaminoacetal derivative and Et3SiH for reduction of the intermediate 4-hydroxy-THIQ. This method is complimentary to the classical Pomeranz-Fritsch and related reactions since it tolerates electron-withdrawing substituents and allows access to 8-substituted THIQs.
Ultrasound assisted one-pot synthesis of benzo-fused indole-4,9-dinones from 1,4-naphthoquinone and α-aminoacetals
Luu, Quang H.,Guerra, Jorge D.,Casta?eda, Cecilio M.,Martinez, Manuel A.,Saunders, Jong,Garcia, Benjamin A.,Gonzales, Brenda V.,Aidunuthula, Anushritha R.,Mito, Shizue
supporting information, p. 2253 - 2256 (2016/05/10)
A one-pot synthesis of benzo[f]indole-4,9-diones from 1,4-naphthoquinone with α-aminoacetals has been developed. This method provides a straightforward synthesis of benzo[f]indole-4,9-diones via intramolecular nucleophilic attack of aminoquinones to aldehydes under mild reaction conditions. The detailed mechanism was also investigated.
