54879-71-9Relevant academic research and scientific papers
Stable and selective hybridization of oligonucleotides with unnatural hydrophobic bases
Berger, Markus,Ogawa, Anthony K.,McMinn, Dustin L.,Wu, Yiqin,Schultz, Peter G.,Romesberg, Floyd E.
, p. 2940 - 2942 (2007/10/03)
Relying on only interbase hydrophobic packing for bonding, several unnatural nucleobases similar to 1 can form selective and stable self-pairs in duplex DNA. These unnatural nucleobases should make it possible to increase the stringency and information co
8,8′-Dialkyl-1,1′-biisoquinolines: Preparation, absolute configuration and unexpected racemization behaviour
Tsue, Hirohito,Fujinami, Hideyuki,Itakura, Takeshi,Tsuchiya, Ryuta,Kobayashi, Kimiko,Takahashi, Hiroki,Hirao, Ken-Ichi
, p. 3677 - 3683 (2007/10/03)
A series of 8,8′-dialkyl-1,1′-biisoquinolines, in which methyl, ethyl and isopropyl groups are introduced for enhancing the transannular steric hindrance, are synthesized. The atropisomeric biisoquinolines are separated into both enantiomers, of which the absolute configurations and the optical stabilities are determined. Contrary to prior expectations, the racemization behaviour is inversely proportional to the steric size of the alkyl groups. The Royal Society of Chemistry 1999.
Preparation of optically active 8,8′-disubstituted 1,1′-biisoquinoline
Hirao, Ken-Ichi,Tsuchiya, Ryuta,Yano, Yasuhiro,Tsue, Hirohito
, p. 415 - 422 (2007/10/02)
Synthesis of 1,1′-biisoquinolines having substituents in the 8,8′-positions and their resolution by hplc on a chiral column on a preparative scale are described.
