54893-23-1

Usage

Uses

Used in Pharmaceutical Industry:
7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline is used as a lead compound for the development of new pharmaceutical drugs due to its potential pharmacological activities.
Used in Neurological Applications:
7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline is used as a potential treatment for neurodegenerative diseases, given its effects on the central nervous system.
Used in Pain Management:
7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline is used as an analgesic agent, leveraging its reported pain-relieving properties.
Used in Anti-inflammatory Applications:
7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline is used as an anti-inflammatory agent, which can be beneficial in managing conditions characterized by inflammation.

Upstream product

• 186581-53-3 diazomethane 
• 88493-58-7 1,2,3,4-tetrahydro-2-methylisoquinolin-7-ol 
• 53366-09-9 N-methyl-7-methoxyisoquinolinium iodide 
• 7647-01-0 hydrogenchloride 
• 50-00-0 formaldehyd 
• 55-81-2 4-Methoxyphenethylamine 
• 91247-71-1 2-4-methoxyphenylethylcarbamic acid methyl ester 
• 22246-04-4 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 39989-39-4 7-methoxyisoquinoline 
• 212184-76-4 N-(2-Benzenesulfinyl-ethyl)-N-(3-methoxy-benzyl)-formamide 
• 212184-93-5 N-(3-Methoxy-benzyl)-N-(2-phenylsulfanyl-ethyl)-formamide 
• 212184-89-9 (3-Methoxy-benzyl)-(2-phenylsulfanyl-ethyl)-amine 
• 591-31-1 3-methoxy-benzaldehyde 
• 221656-37-7 N,N-bis(1H-1,2,3-benzotriazol-1-ylmethyl)-N-(4-methoxyphenethyl)amine 

Downstream Products

• 1187947-97-2 1-[2-methyl-7-(2-morpholin-4-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol 
• 1620820-70-3 6-methoxy-1-(3,4-dimethoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1620820-69-0 6-methoxy-1-(3-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 88493-58-7 1,2,3,4-tetrahydro-2-methylisoquinolin-7-ol 

Relevant academic research and scientific papers

Pd-catalyzed ortho-arylation of 3,4-dihydroisoquinolones via C-H bond activation: synthesis of 8-aryl-1,2,3,4-tetrahydroisoquinolines

An efficient route to synthesize biologically interesting 8-aryl-1,2,3,4-tetrahydroisoquinoline has been developed. It involves the Pd-catalyzed direct arylation of 3,4-dihydroisoquinolones via C-H bond activation with aryl iodides to afford a variety of 8-arylated cross-coupling products, which are subsequently reduced to 8-aryl-1,2,3,4-tetrahydroisoquinolines in good to excellent yields.

NOVEL MONOAMINE RE-UPTAKE INHIBITOR

The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also rel

2-Substituted-1,2,3,4-tetrahydroisoquinolines and chiral 3-carboxyl analogues from N-benzotriazolylmethyl-N-phenethylamines

N-Benzotriazolylmethyl-N-phenethylamines 5a-5c and 11a-11c cyclize in the presence of aluminum chloride to produce 1,2,3,4-tetrahydroisoquinolines 6a-6c and 12a-12c (70-89%) via electrophilic attack of a transient iminium cation X on the tethered phenyl r

Synthesis of some N-methyl-1,2,3,4-tetrahydroisoquinolines by Friedel-Crafts cyclisation using benzotriazole auxiliary

1-Hydroxymethylbenzotriazole reacts with phenylethylamines to give the respective N,N-bis(benzotriazol-1-ylmethyl)phenylethylamines, which are then subject to an intramolecular Friedel-Crafts cyclisation at room temperature to yield N-benzotriazol-1-ylmet

A synthesis of mono- and dimethoxy-1,2,3,4-tetrahydroisoquinolines via Pummerer reaction: Effects of methoxyl groups on intramolecular cyclization

A synthesis of 1,2,3,4-tetrahydroisoquinolines (TIQs) (23) with one and two methoxyl groups at various positions of the benzene ring was achieved via the intramolecular cyclization of N-(aryl)methyl-2- (phenylsulfinyl)ethylamines (9) using the Pummerer reaction as a key step. The reaction was carried out by using trifluoroacetic anhydride (TFAA) (method A) or TFAA-BF3 · Et2O (method B). The cyclization to 4-SPhTIQs (11) proceeded effectively when the reaction center at the benzene ring was electronically activated by a methoxyl group. In the reaction of the sulfoxide (9e) having two OMe groups at ortho- and para-positions a different cyclization reaction leading to a benzothiazepine (12) was observed, indicating that the high nucleophilicity of the benzene ring caused the unexpected reaction prior to the cyclization to 4-SPhTIQ (11e). The route starting from methoxylated benzaldehydes (5) was proved to provide an efficient and convenient method of TIQ synthesis which should be complementary to the well known Pictet-Spengler method.