54893-95-7

Basic information

• Product Name: Butanoic acid, 2-[bis(methylthio)methylene]-3-oxo-, ethyl ester
• Synonyms: 2-Acetyl-3,3-bis-methylmercapto-acrylsaeure-aethylester;ethyl 3,3-bismethylthio-2-acetylacrylate;acetyl-ethoxycarbonyl-ketene dimethyl dithioacetal;Butanoic acid,2-[bis(methylthio)methylene]-3-oxo-,ethyl ester;2-acetyl-3,3-bis-methylsulfanyl-acrylic acid ethyl ester;ethyl 2-(bis(methylthio)methylene)-3-oxobutanoate;ethyl 2-acetyl-3,3-bis(methylthio)acrylate
• CAS NO: 54893-95-7
• Molecular Formula: C9H14O3S2
• Molecular Weight: 234.34
• Mol File: 54893-95-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[bis(methylthio)methylene]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[bis(methylthio)methylene]-3-oxo-, ethyl ester(54893-95-7)
• EPA Substance Registry System: Butanoic acid, 2-[bis(methylthio)methylene]-3-oxo-, ethyl ester(54893-95-7)

Safety Data

• Hazardous Substances Data: 54893-95-7(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 60-29-7 diethyl ether 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 141-97-9 ethyl acetoacetate 
• 74-88-4 methyl iodide 
• 74-83-9 methyl bromide 
• 20412-62-8 enolate sodique de l'acetylacetate d'ethyle 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 17649-86-4 4,4-bis(methylthio)but-3-en-2-one 
• 555154-34-2 ethyl 2-acetyl-3-methyl-5-methylsulfanylthiophene-4-carboxylate 
• 555154-33-1 diethyl 3-methyl-5-methylsulfanylthiophene-2,4-dicarboxylate 
• 1259434-11-1 ethyl 3-methyl-5-(methylthio)-1-phenyl-1H-pyrazole-4-carboxylate 
• 1425383-91-0 ethyl 4-formyl-6-(methylthio)-2-phenylpyrimidine-5-carboxylate 
• 1425383-92-1 4-(methylthio)-2-phenylpyrimido[4,5-d]pyridazin-5(6H)-one 
• 1425379-71-0 4-(4-morpholinophenylamino)-2-phenylpyrimido[5,4-d]pyridazin-5(6H)-one 
• 1425387-25-2 C₁₃H₁₀N₄O₃S 
• 13995-89-6 ethyl 4-methyl-6-(methylthio)-2-phenylpyrimidine-5-carboxylate 
• 1443426-62-7 ethyl methyl 2-hydroxy-3-methyl-6-methylthio-isophthalate 
• 92807-28-8 5,5-Bis-methylmercapto-1-(4-methoxy-phenyl)-pentadien-1,4-on-3 
• 92807-26-6 Cinnamoylketene S,S-dimethyl acetal 

Relevant articles and documents

Palladium-Catalyzed C-S Bond Cleavage with Allenoates: Synthesis of Tetrasubstituted 2-Alkenylfuran Derivatives

Palladium-catalyzed C-S cleavage of tetrasubstituted internal alkene α-oxo ketene dithioacetals was realized with allenoates as the coupling partners, efficiently affording tetrasubstituted 2-alkenylfuran derivatives with excellent regioselectivity under mild conditions. Allenoates acted as C1 synthons in the desulfurative [4 + 1] annulation.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

The invention relates to novel heteroaryl and heterocycle compounds of formula I and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.

PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF

The present application provides novel pyrimido-pyridazinone compounds and methods for preparing and using these compounds. These compounds are useful in treating inflammation in patients by administering one or more of the compounds to a patient. In one embodiment, the novel pyrimido-pyridazinone compound is of Formula (I) and R1 and R2 are defined herein.