54893-95-7

Upstream product

• 75-15-0 carbon disulfide 
• 141-97-9 ethyl acetoacetate 
• 74-88-4 methyl iodide 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 74-83-9 methyl bromide 
• 20412-62-8 enolate sodique de l'acetylacetate d'ethyle 
• 77-78-1 dimethyl sulfate 
• 60-29-7 diethyl ether 

Downstream Products

• 17649-86-4 4,4-bis(methylthio)but-3-en-2-one 
• 555154-34-2 ethyl 2-acetyl-3-methyl-5-methylsulfanylthiophene-4-carboxylate 
• 555154-33-1 diethyl 3-methyl-5-methylsulfanylthiophene-2,4-dicarboxylate 
• 1259434-11-1 ethyl 3-methyl-5-(methylthio)-1-phenyl-1H-pyrazole-4-carboxylate 
• 13995-89-6 ethyl 4-methyl-6-(methylthio)-2-phenylpyrimidine-5-carboxylate 
• 1425383-91-0 ethyl 4-formyl-6-(methylthio)-2-phenylpyrimidine-5-carboxylate 
• 1425383-92-1 4-(methylthio)-2-phenylpyrimido[4,5-d]pyridazin-5(6H)-one 
• 1425379-71-0 4-(4-morpholinophenylamino)-2-phenylpyrimido[5,4-d]pyridazin-5(6H)-one 
• 1425387-25-2 C₁₃H₁₀N₄O₃S 
• 1443426-62-7 ethyl methyl 2-hydroxy-3-methyl-6-methylthio-isophthalate 
• 92807-28-8 5,5-Bis-methylmercapto-1-(4-methoxy-phenyl)-pentadien-1,4-on-3 
• 92807-26-6 Cinnamoylketene S,S-dimethyl acetal 

Relevant academic research and scientific papers

Palladium-Catalyzed C-S Bond Cleavage with Allenoates: Synthesis of Tetrasubstituted 2-Alkenylfuran Derivatives

Palladium-catalyzed C-S cleavage of tetrasubstituted internal alkene α-oxo ketene dithioacetals was realized with allenoates as the coupling partners, efficiently affording tetrasubstituted 2-alkenylfuran derivatives with excellent regioselectivity under mild conditions. Allenoates acted as C1 synthons in the desulfurative [4 + 1] annulation.

Controlled Ring-Opening of Siloxydifluorocyclopropanes for Carbocyclization: Synthesis of Difluorocyclopentenones

A highly controlled ring opening of siloxydifluorocyclopropanes, formed by nBuN4Br-catalyzed difluorocyclopropanation of methyl vinyl ketones bearing a β-alkylthio group by using TMSCF2Br as a unique difluorocarbene source, results in metal difluorohomoenolates with assistance of copper or silver followed by an intramolecular addition and elimination reaction leading to α-gem-difluorocyclopentenones efficiently.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

The invention relates to novel heteroaryl and heterocycle compounds of formula I and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.

Regioselective synthesis of 3-(methylthio)phenols by formal [3+3]-cyclocondensations of 3-oxo-bis(methylthio)ketenacetals with 1,3-bis(trimethylsilyloxy)-1,3-butadienes and 1,3-dicarbonyl dianions

The cyclization of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-oxo-bis(methylthio)ketenacetals afforded 3-(methylthio)phenols containing an acyl or ester substituent located at position 2. The cyclization of free 1,3-dicarbonyl dianions with 3-oxo-bi

PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF

The present application provides novel pyrimido-pyridazinone compounds and methods for preparing and using these compounds. These compounds are useful in treating inflammation in patients by administering one or more of the compounds to a patient. In one embodiment, the novel pyrimido-pyridazinone compound is of Formula (I) and R1 and R2 are defined herein.

Aerobic, Cu-catalyzed desulfitative C-C bond-forming reaction of ketene dithioacetals/vinylogous thioesters and arylboronic acids

A new Cu-catalyzed thioorganic-boronic acid desulfitative C-C bond-forming reaction involving ketene dithioacetals/ vinylogous thioesters is reported to proceed without the assistance of ligating S-pendant. Vinylogous thiolesters and tetrasubstituted olefins were prepared by this reaction in which Cu catalyst plays a dual role under aerobic conditions.

Unexpected hydrobromic acid-catalyzed C-C bond-forming reactions and facile synthesis of coumarins and benzofurans based on ketene dithioacetals

Hydrobromic acid was found to be a unique catalyst in C-C bond-forming reactions with ketene dithioacetals. Distinctly different from other acids (including Lewis and Bronsted acids), the remarkable catalytic performance of hydrobromic acid in catalytic a

Synthesis of substituted isoxazoles and pyrazoles from α-α Dioxoketen dithioacetals under solvothermal conditions

Some new 3,4,5-substituted isoxazoles, 3,4,5 and 1,3,4,5-substituted pyrazoles were prepared by reaction of,-oxoketen dithioacetals with hydroxylamine hydrochloride; phenyl hydrazine and hydrazine hydrate respectively under solvothermal conditions involving an ecofriendly method without any environmental pollution. The yields are in the range of 71-91%. The structure of the new compounds were established upon their elemental analysis, IR, 1H NMR, and 13C NMR. Copyright Taylor & Francis Group, LLC.

One-pot synthesis of polyfunctionalized 4H-chromenes and dihydrocoumarins based on copper(II) bromide-catalyzed C-C coupling of benzylic alcohols with ketene dithioacetals

The synthesis of polyfunctionalized 4Hchromenes 3 and dihydrocoumarins 4 has been developed from the same substrates. Catalyzed by copper(II) bromide (0.3 equiv.), the reactions of the easily available ketene dithioacetals 1 with 2-(hydroxymethyl)phenols 2 lead to 4/7-chromenes 3 in high to excellent yields in dichloromethane solvent, whereas, 3,4-trans-disubstituted dihydrocoumarins 4 are obtained in high yields with high diastereoselectivities by prolonging the reaction time or changing the solvent from dichloromethane to acetonitrile.

Synthesis of functionalized allylic sulfoxides and their use in the construction of 2,3,4-trisubstituted furans via a [3 + 2] annulation

(Chemical Equation Presented) A route to 2,3,4-trisubstituted furan derivatives based on a [3 + 2] annulation of functionalized allylic sulfoxides and aldehydes is described. In this strategy, the precursors of allylic sulfoxides 4, allylic sulfides 3, were synthesized via a thiomethylation reaction of an α-EWG ketene-S,S-acetal 1 (EWG: electron-withdrawing group), formaldehyde, and a thiol 2 in high to excellent yields. Allylic sulfoxides 4 were prepared by a highly regioselective oxidation of 3, using m-chloroperoxybenzoic acid as oxidant. Thus, starting from these readily available sulfoxides 4, 2-alkylthio-3,4-disubstituted furans 6 were efficiently constructed via the [3 + 2] annulation reaction of 4 with aldehydes 5 under mild conditions. Further replacement of the 2-alkylthio group of 6 with amines led to the formation of 2-amino-3,4-disubstituted furan derivatives 7.