54898-34-9 Usage
Uses
Used in Antiviral Applications:
2'-chlorothymidine is used as an antiviral agent due to its potential to interfere with viral replication processes, thereby inhibiting the spread of viruses.
Used in Antitumor Applications:
2'-chlorothymidine is used as an antitumor agent for its potential to disrupt the replication and function of tumor cells, offering a possible therapeutic approach for cancer treatment.
Used in Research:
2'-chlorothymidine is used as a nucleic acid labeling and tracking agent in research, allowing scientists to study the behavior and interactions of nucleic acids in various biological processes.
Used in Cancer Imaging:
2'-chlorothymidine is used as a diagnostic tool in cancer imaging, potentially aiding in the detection and monitoring of cancerous cells due to its interaction with DNA and its effects on biological processes.
Used in Pharmaceutical Development:
The chloro group on the 2' carbon of 2'-chlorothymidine could alter the base pairing properties and overall structure of DNA, which may impact its function in biological processes. This characteristic is being explored for the development of new pharmaceuticals targeting specific diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 54898-34-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,8,9 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 54898-34:
(7*5)+(6*4)+(5*8)+(4*9)+(3*8)+(2*3)+(1*4)=169
169 % 10 = 9
So 54898-34-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H13ClN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)
54898-34-9Relevant academic research and scientific papers
Method for preparing β-thymidine
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Paragraph 0111-0113, (2018/02/04)
The invention relates to a preparation method of beta-thymidine, and specifically discloses a method of preparing beta-thymidine from the formula II compound. The method comprises following steps: subjecting the compound represented as the formula II to carry out dehalogenation reactions, in a hydrogen atmosphere, in the presence of a catalyst, and in a buffer system with a pH value of 6.5 to 8.0, so as to obtain beta-thymidine represented as the formula I, wherein X represents Cl or Br. The dehalogenation reactions are carried out under atmospheric pressure, and the preparation method has the advantages of environment-friendliness, economy, high product yield, good product purity, and suitability for industrial production.
Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Vanheusden, Veerle,Munier-Lehmann, Helene,Pochet, Sylvie,Herdewijn, Piet,Van Calenbergh, Serge
, p. 2695 - 2698 (2007/10/03)
A number of 2′- and 3′-modified thymidine 5′-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2′-halogeno substituent and a 3′-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.
