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10-Hydroxyestra-1,4-diene-3,17-dione, also known as 10-hydroxyestra-1,4-diene-3,17-dione or 10-hydroxy-1,4-estradienedione, is a naturally occurring steroidal compound derived from the parent compound estrone. It is a metabolite of estrogen and plays a significant role in the endocrine system, particularly in the regulation of various physiological processes such as bone metabolism, cardiovascular health, and reproductive functions. 10-hydroxyestra-1,4-diene-3,17-dione is characterized by its unique chemical structure, featuring a hydroxyl group at the 10th carbon position, a double bond between the 1st and 4th carbon atoms, and ketone groups at the 3rd and 17th carbon positions. Due to its potential therapeutic applications, 10-hydroxyestra-1,4-diene-3,17-dione has been the subject of various scientific studies, with ongoing research aimed at understanding its effects on human health and potential use in the development of novel pharmaceuticals.

549-03-1

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549-03-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 549-03-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 549-03:
(5*5)+(4*4)+(3*9)+(2*0)+(1*3)=71
71 % 10 = 1
So 549-03-1 is a valid CAS Registry Number.

549-03-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 10-Hydroxyestra-1,4-diene-3,17-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:549-03-1 SDS

549-03-1Relevant academic research and scientific papers

Electrophilic hydroxylation of aromatics in superacids

Jacquesy, Jean-Claude,Berrier, Christian,Gesson, Jean-Pierre,Jouannetaud, Marie-Paule

, p. 658 - 664 (2007/10/02)

In superacids, protonated hydrogen peroxide hydroxylates various aromatics to give phenols.The substrates react in their protonated forms with the electrophile H3O2+.Phenols (and their methyl ethers), anilines, indolines, indoles, aromatic aldehydes and ketones are hydroxylated without any degradation; protonation protects the functional group(s) that are normally sensitive to oxidants.Electrophilic hydroxylation of polyfunctional natural products (vincadifformine, estrane derivatives) has been succesfully performed with H2O2/HF/SbF5. - Keywords: superacids / hydroxylation / hydrogen peroxide / aromatics / phenols / indoles

Chemical evidence for peroxy radicals intermediacy in copper(II) reaction with hydroperoxides

Maumy, Michel,Capdevielle, Patrice

, p. 7455 - 7462 (2007/10/02)

Two unprecedented decompositions of tertiary hydroperoxides by Cu(II) in CH3CN have been encountered : deoxygenation of 4- hydroperoxy cyclohexa 2,5- dienones 1 and 2 brings chemical support to the existence of intermediate peroxy radicals R-OO· 1′ and 2′.

HYDROXYLATION DE L'ESTRONE ET DE SON ACETATE PAR LE PEROXYDE D'HYDROGENE EN MILIEU SUPERACIDE

Berrier, C.,Jacquesy, J. C.,Jouannetaud, M. P.

, p. 5135 - 5142 (2007/10/02)

Estrone 1a and its acetate 1b react with hydrogen peroxide in SbF5-HF to give hydroxylated compounds.The formation of the dienone 2 can be accounted for by reaction of the electrophile H3O2+ on the neutral substrate, whereas formation of compound 3b implies electrophilic attack on the protonated ester 1b.Higher acidity favours rearrangement of the resulting ion 9 to yield, through a spiro intermediate, the ester 4b.Under the reaction conditions esters 3b and 4b are slowly converted into the corresponding phenols 3a and 4a.

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