54911-85-2

Basic information

• Product Name: Butanal, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-
• Synonyms: Butanal, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-;4-(2-Tetrahydropyranyloxy)butyraldehyde;4-[(Tetrahydro-2H-pyran-2-yl)oxy]butanal
• CAS NO: 54911-85-2
• Molecular Formula: C₉H₁₆O₃
• Molecular Weight: 172.22
• Product Categories: Aliphatics
• Mol File: 54911-85-2.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 58-60 °C(Press: 0.5 Torr)
• Appearance: /
• Density: 1.01±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• CAS DataBase Reference: Butanal, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanal, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-(54911-85-2)
• EPA Substance Registry System: Butanal, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-(54911-85-2)

Safety Data

• Hazardous Substances Data: 54911-85-2(Hazardous Substances Data)

Usage

Chemical Properties

Brown Liquid

Uses

4-Tetrahydropyranyloxy-butanal is a useful building block.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 64841-44-7 5-<2'-(tetrahydropyranyloxy)>-1-pentene 
• 59574-65-1 2-(3-butenyloxy)tetrahydropyran 
• 51326-51-3 4-(tetrahydropyran-2-yloxy)butan-1-ol 
• 93691-87-3 methyl 4-hydroxybutyrate tetrahydropyran-2-yl ether 

Downstream Products

• 323198-43-2 (R)-[(Z)-5-(tetrahydro-2H-pyran-2-yloxy)-1-pentenyl] p-tolyl sulfoxide 
• 323198-42-1 (R)-[(E)-5-(tetrahydro-2H-pyran-2-yloxy)-1-pentenyl] p-tolyl sulfoxide 
• 444682-16-0 (Z)-(2S,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethyl-9-(tetrahydropyran-2-yloxy)non-5-en-1-yl tert-butyldimethylsilyl ether 
• 623926-77-2 tert-Butyl-[(4Z,9Z)-(1R,6S,7R,8S)-7-(4-methoxy-benzyloxy)-1-[(Z)-(1R,2S,3S)-2-(4-methoxy-benzyloxy)-1,3-dimethyl-hepta-4,6-dienyl]-6,8-dimethyl-13-(tetrahydro-pyran-2-yloxy)-trideca-4,9-dienyloxy]-dimethyl-silane 
• 850474-19-0 4-Methoxy-benzoic acid 4-(tetrahydro-pyran-2-yloxy)-1-vinyl-butyl ester 
• 190258-39-0 1-Phenyl-6-<(tetrahydro-2H-pyran-2-yl)oxy>-1-hexyn-3-ol 
• 1330745-73-7 C₂₇H₄₂O₄Si 
• 1206193-24-9 C₁₈H₂₆O₄ 
• 180-84-7 1,7-dioxaspiro[5.5]undecane 
• 155193-01-4 1-Phenyl-3-<(2-propenyl)oxy>-6-<(tetrahydro-2H-pyran-2-yl)oxy>-1-hexyne 

Relevant articles and documents

Double cationic propargylation: From linear to polycyclic ethers

Equation presented The trapping of cations generated from Co2(CO)6-bispropargylic alcohols provided diethers in good yield. The procedure is also valid when two vicinal acetylenes are present. The methodology can be applied to the sy

A scalable synthesis of (+)-coronafacic acid

A facile, efficient, and scalable synthesis of optically pure coronafacic acid by resolution of racemic coronafacic acid obtained using an improved version of Watson's method has been developed. By optimizing the boron-mediated aldol reaction of Watson, we were able to prepare 2.1 g of racemic coronafacic acid. This was coupled with (S)-4-isopropyl-2-oxazolidinone to give a mixture of diastereomeric coronafacyl oxazolidinones, which were readily separable by silica-gel column chromatography to give 630 mg of optically pure (+)-coronafacic acid.

Synthesis method of aggregation pheromone (E)-cis-6, 7-epoxy-2-nonenal of Aromia bungii

The invention relates to a synthesis method of aggregation pheromone (E)-cis-6, 7-epoxy-2-nonenal of Aromia bungii, which belongs to the field of pharmaceutical synthesis. The synthesis method comprises the following steps: taking 1, 4-butanediol as a raw material, singly protecting diol with DHP (dihexylphthalate) and then oxidizing TEMPO (tetramethylpiperidine oxide) into 4-((tetrahydro-2H-pyran-2-base) oxy) butyraldehyde; performing a Wittig reaction, so as to obtain (Z)-2-(hepta-4- alkene-1-base-oxy) tetrahydro-2H-pyran; removing the protection of the DHP and oxidizing TEMPO, so as to obtain (Z)-4-heptenal; performing a Wittig reaction, so as to obtain (2E, 6Z)-nona-2, 6-heptadienal; finally, performing epoxidation, so as to obtain the aggregation pheromone (E)-cis-6, 7-epoxy-2-nonenalof the Aromia bungii. The total yield is 6.5%. In the synthesis method, the 1, 4-butanediol with low cost is taken as the starting raw material; the synthesis method has the advantages of being simple in operation and mild in conditions, therefore, the synthesis method is suitable for large-scale preparation.

Au-catalyzed intramolecular hydroalkoxylation of gem-difluorinated alkynols

The intramolecular hydroalkoxylation of gem-difluorinated alkynols was found possible under Au catalysis, allowing for the preparation of a series of fluorinated heterocycles. The nature of the solvent was found to be especially critical in the cyclizatio