444682-16-0Relevant academic research and scientific papers
Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide
Minguez, Jose M.,Kim, Sun-Young,Giuliano, Kenneth A.,Balachandran, Raghavan,Madiraju, Charitha,Day, Billy W.,Curran, Dennis P.
, p. 3335 - 3357 (2007/10/03)
An efficient, convergent and stereocontrolled synthesis of simplified analogues of the potent antimitotic agent (+)-discodermolide has been achieved and several small libraries have been prepared. In all the libraries, the discodermolide methyl groups at
Simultaneous preparation of four truncated analogues of discodermolide by fluorous mixture synthesis
Curran, Dennis P.,Furukawa, Takashi
, p. 2233 - 2235 (2007/10/03)
(matrix presented) Four analogues made in one synthesis Four truncated analogues of the natural product discodermolide were synthesized in a single synthetic sequence. Precursors bearing four different groups at C22, each with a unique fluorous p-methoxyb
