54920-98-8

Usage

Uses

Used in Pharmaceutical Chemistry:
2-Amino-2-carboxydiphenylsulphide is used as a synthetic intermediate for the development of pharmaceutical compounds, leveraging its unique functional groups to form various salts and exhibit pH-dependent behavior. Its ability to interact with other molecules makes it a valuable component in the synthesis of new drugs and therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 2-Amino-2-carboxydiphenylsulphide serves as a model compound for studying the properties and reactions of compounds containing amino, carboxyl, and sulfoxide functional groups. Researchers use 2-Amino-2-carboxydiphenylsulphide to explore its reactivity, stability, and potential applications in various chemical processes and reactions.
Used in Material Science:
2-Amino-2-carboxydiphenylsulphide may also find applications in material science, where its unique chemical structure and functional groups can be utilized to develop new materials with specific properties. For instance, it could be used in the synthesis of polymers, coatings, or other materials with tailored characteristics for various industrial applications.

InChI:InChI=1/C13H11NO2S/c14-10-6-2-4-8-12(10)17-11-7-3-1-5-9(11)13(15)16/h1-8H,14H2,(H,15,16)

Upstream product

• 147-93-3 Thiosalicylic acid 
• 19806-43-0 2?(2?nitrophenylsulfanyl)benzoic acid 
• 7440-02-0 nickel 
• 1493-27-2 ortho-nitrofluorobenzene 
• 4892-02-8 Methyl thiosalicylate 
• 88-73-3 2-Chloronitrobenzene 
• 609-73-4 o-nitroiodobenzene 

Downstream Products

• 3159-07-7 dibenzo[b,f][1,4]thiazepin-11-one 
• 63094-10-0 4-amino-9H-thioxanthen-9-one 
• 63094-12-2 2-(2-acetylaminophenylthio)benzoic acid 
• 30690-43-8 dibenzo-1,4-thiazepin-11(10H)-thione 
• 5747-49-9 11-hydrazinodibenzo-1,4-thiazepine 
• 49781-37-5 dibenzo-1,2,4-triazolo<4,3-d>-1,4-thiazepine 
• 87213-34-1 3-bromodibenzo-1,2,4-triazolo<4,3-d>-1,4-thiazepine 
• 13745-86-3 11-chloro-dibenzo[b,f][1,4]thiazepine 

Relevant academic research and scientific papers

Antibodies to quetiapine haptens and use thereof

Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

Antibodies to Quetiapine Haptens and Use Thereof

Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

HAPTENS OF QUETIAPINE FOR USE IN IMMUNOASSAYS

The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.

Process for preparing dibenzothiazepine compounds

A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2′-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2′-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2′-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2′-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.

IRON CATALYZED CROSS-COUPLING REACTIONS OF IMIDOYL DERIVATIVES

Disclosed is a process for preparing a compound of formula A - N=C(D)(B), from a compound of formula A-N=C(E)(B) and a compound of formula D-M using an iron catalyst, where the process has is represented by Equation (I).

PROCESS FOR PRODUCING 11-[4-[2-(2-HYDROXYETHOXY)ETHYL]-1-PIPERAZINYL]DIBENZO[b,f][1,4]THIAZEPINE AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

A process for producing 11-[4-[2-(2-hydroxyethoxy)ethyl]-l-piperazinyl]dibenzo [b,f][1,4]thiazepine [I] and a pharmaceutically suitable acid addition salt is disclosed. Accordingly, thiosalicylic acid [XVI] is reacted with o-halonitrobenzene [XVII] using a phase transfer catalyst to obtain 2-nitro-2'-carboxydiphenylsulphide [XI]. It is hydrogenated in the presence of a noble metal catalyst to obtain 2-amino-2' carboxydiphenyl sulphide [X]. The 2-amino-2'-carboxydiphenylsulphide [X] is reacted with halide or oxyhalide of the phosphorous to obtain in situ iminohalide [VI], which further reacts as such with 1-hydroxyethoxyethylpiperazine or condenses with piperazine to obtain 11-piperazinyldi.benzo[b,f][1,4]thiazepine [XIX] which further reacts with 2- chloroethoxyethanol or reacts with 1-(2-hydroxyethyl)piperazine to give 11-[4-(2-hydroxyethyl)piperazine-1-yl]dibenzo[b,f][ 1,4]thiazepine [XXXI] which further converts to an intermediate 11-[4-(2-substitutedethyl)piperazin-1- yl)dibenzo[b,f][1,4]thiazepine wherein the substituent at the 2-position is selected from mesyloxy or tosyloxy or halo group [XXXII] followed by reaction with ethylene glycol to give quetiapine [1].

PROCESS FOR PRODUCING DIBENZOTHIAZEPINE DERIVATIVES

A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f] [1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldiberizothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2'-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2'-carboxy-diphenylsulfide derivative to dehydration-condensation reaction.

NOVEL REACTIONS OF SPIROSULFURANE PRECURSOR SULFIDES AND SULFOXIDES

The SIV spirosulfurane 19 and the lactam-sulfoxides 21, 22 and 23 with seven-, eight- and nine-membered rings have been prepared by oxidation and dehydration of trifluoroacetylaminoarylcarboxyphenyl sulfides and sulfoxides, respectively.A mechanism is proposed for the formations of lactam-sulfoxides.The preparation of the starting sulfides and sulfoxides is also described. Key words: Diaryl sulfides; diaryl sulfoxides; spirosulfurane; lactams; carboxyl activation; lactam-sulfoxide formation.