54926-15-7

Upstream product

• 64-19-7 acetic acid 
• 13214-64-7 N-(4-methoxybenzoyl)glycine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 201230-82-2 carbon monoxide 
• 68-12-2 N,N-dimethyl-formamide 
• 13443-58-8 N-(2-methoxybenzoyl)glycine 
• 3424-93-9 4-methoxyphenylacetamide 
• 124-38-9 carbon dioxide 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 77287-34-4 formamide 
• 54926-13-5 N-[1-Dimethylamino-meth-(E)-ylidene]-4-methoxy-benzamide 

Relevant academic research and scientific papers

An NHC-Stabilised Phosphinidene for Catalytic Formylation: A DFT-Guided Approach

In recent years, the applications of low-valent main group compounds have gained momentum in the field of catalysis. Owing to the accessibility of two lone pairs of electrons, NHC-stabilised phosphinidenes have been found to be excellent Lewis bases; however, they cannot yet be used as catalysts. Herein, an NHC-stabilised phosphinidene, 1,3-dimethyl-2-(phenylphosphanylidene)-2,3-dihydro-1H imidazole (1), for the activation of CO2 is reported.A closer inspection of the CO2 activation process by DFT calculations along with intrinsic bond orbital analysis shows that phosphinidene is associated with phenylsilane through a noncovalent π-π interaction between two phenyl rings which activates the Si?H bond facilitating hydride transfer to the CO2 molecule. Detailed DFT studies along with spectroscopic experiments were combined to understand the mechanism of CO2 activation and its catalytic reductive functionalisation leading to the formylation of a range of chemically inert primary amides under mild reaction conditions.

Designing a Cr-catalyst bearing redox non-innocent phenalenyl-based ligand towards hydrosilylative CO2functionalization

Herein, we report the synthesis of a Cr(iii)-complex bearing a redox non-innocent phenalenyl-based ligand and its use as a catalyst for SET mediated hydrosilylative reduction of carbon dioxide towards formylation of primary amides under mild conditions. A

Facile access to: N-formyl imide as an N-formylating agent for the direct synthesis of N-formamides, benzimidazoles and quinazolinones

N-Formamide synthesis using N-formyl imide with primary and secondary amines with catalytic amounts of p-toluenesulfonic acid monohydrate (TsOH·H2O) is described. This reaction is performed in water without the use of surfactants. Moreover, N-formyl imide is efficiently synthesized using acylamidines with TsOH·H2O in water. In addition, N-formyl imide was successfully used as a carbonyl source in the synthesis of benzimidazole and quinazolinone derivatives. Notable features of N-formylation of amines by using N-formyl imide include operational simplicity, oxidant- A nd metal-free conditions, structurally diverse products, and easy applicability to gram-scale operation.

An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P)

An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields.

A facile synthesis of N-formylbenzamides by oxidative decarboxylation of N-aroylglycine induced by Ag+/S2O82-

A facile method is described for the synthesis of N-formylbenzamides by oxidative decarboxylation of N-aroylglycine using catalytic silver(I) and 2 equivalents of ammonium persulfate as an oxidant in a biphasic system (CHCl 3/water).

Synthesis of unsymmetrical aroyl acyl imides by aminocarbonylation of aryl bromides

Aroyl imides were prepared by a palladium-catalyzed aminocarbonylation reaction of aryl bromides with carbon monoxide and primary amides in good yields (58-72%). The reactions were carried out under mild conditions (5 bar, 120 °C) using 1 mol % of a palla

The Oxidative Decarboxylation of N-Aroylglycines to N-(Aacetoxymethyl)benzamides and N-Formylbenzamides with Lead(IV) Acetate

Treatment of N-aroylglycines that do not bear a strong electron-withdrawing substituents with lead(IV) acetate in acetic acid/acetic anhydride mixtures at 60-100 deg C rapidly gives the corresponding N-(acetoxymethyl)benzamides and N-formylbenzamides in m