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Benzenamine, 3-chloro-4-(cyclohexyloxy)-, also known as 3-Chloro-4-cyclohexyloxyaniline, is an organic compound with the chemical formula C12H16ClNO. It is a derivative of aniline, featuring a chloro group at the 3-position and a cyclohexyloxy group at the 4-position. Benzenamine, 3-chloro-4-(cyclohexyloxy)- is characterized by its aromatic structure, with a benzene ring and an amino group attached to it. It is used in the synthesis of various pharmaceuticals and agrochemicals due to its unique chemical properties, which allow it to form a range of different compounds through substitution and other chemical reactions. The presence of the cyclohexyloxy group provides steric hindrance and can influence the reactivity and selectivity of the molecule in chemical transformations.

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  • 5493-78-7 Structure
  • Basic information

    1. Product Name: Benzenamine, 3-chloro-4-(cyclohexyloxy)-
    2. Synonyms:
    3. CAS NO:5493-78-7
    4. Molecular Formula: C12H16ClNO
    5. Molecular Weight: 225.718
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 5493-78-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Benzenamine, 3-chloro-4-(cyclohexyloxy)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Benzenamine, 3-chloro-4-(cyclohexyloxy)-(5493-78-7)
    11. EPA Substance Registry System: Benzenamine, 3-chloro-4-(cyclohexyloxy)-(5493-78-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 5493-78-7(Hazardous Substances Data)

5493-78-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5493-78-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,9 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5493-78:
(6*5)+(5*4)+(4*9)+(3*3)+(2*7)+(1*8)=117
117 % 10 = 7
So 5493-78-7 is a valid CAS Registry Number.

5493-78-7Downstream Products

5493-78-7Relevant articles and documents

4′-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents

Jin, Yi,Zhou, Zu-Yu,Tian, Wei,Yu, Qiang,Long, Ya-Qiu

, p. 5864 - 5869 (2007/10/03)

Mitosis inhibitors are powerful anticancer drugs. Based on a novel anti-microtubule agent of 5-(4′-methoxy)anilino-4-hydroxy-8-nitroquinazoline, a series of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8- nitroquinazolines were designed and synthesized to investigate the effect of the substitution on the inhibitory activity against mitotic progression of tumor cells. The large alkoxyl substitution on the 4′-position of 5-anilino ring is beneficial for the potency. The 5-(3′,4′,5′-trimethoxy)anilino-8-nitroquinazoline (1h) displays an overwhelming activity in arresting the cells at the G2/M phase, providing a promising new template for further development of potent microtubule-targeted anti-mitotic drugs.

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