54943-19-0

Basic information

• Product Name: 3-methyl-6-propanoyl-1,3-benzoxazol-2(3H)-one
• CAS NO: 54943-19-0
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.2099
• Mol File: 54943-19-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 343.9°C at 760 mmHg
• Flash Point: 161.8°C
• Density: 1.242g/cm³
• Vapor Pressure: 6.82E-05mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: 3-methyl-6-propanoyl-1,3-benzoxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-6-propanoyl-1,3-benzoxazol-2(3H)-one(54943-19-0)
• EPA Substance Registry System: 3-methyl-6-propanoyl-1,3-benzoxazol-2(3H)-one(54943-19-0)

Safety Data

• Hazardous Substances Data: 54943-19-0(Hazardous Substances Data)

Upstream product

• 33388-19-1 3-propionylbenzo[d]oxazol-2(3H)-one 
• 59-49-4 2-Benzoxazolinone 
• 54903-11-6 6-propanoyl-3H-1,3-benzoxazol-2-one 
• 74-87-3 methylene chloride 
• 21892-80-8 3-methylbenzo[d]oxazol-2(3H)-one 
• 123-62-6 propionic acid anhydride 
• 802294-64-0 propionic acid 

Downstream Products

• 54903-58-1 1-(3-Hydroxy-4-methylamino-phenyl)-propan-1-one 
• 131363-46-7 3-methyl-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-methylpropionyl}benzoxazolinone 
• 131363-44-5 3-methyl-6-{3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]-2-methylpropionyl}benzoxazolinone 
• 134577-30-3 2,4-Dimethyl-7-propionyl-4H-benzo[1,4]oxazin-3-one 
• 134577-33-6 7-(2-methylenepropionyl)-2,4-dimethyl-3,4-dihydro-3-oxo-1,4(2H)benzoxazine 
• 134577-34-7 7-(2-methylenepropionyl)-2,2,4-trimethyl-3,4-dihydro-3-oxo-1,4(2H)benzoxazine 

Relevant articles and documents

Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)- benzothiazolone derivatives

A series of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives were synthesized and evaluated for anticonvulsant activity. The compounds were assayed, intraperitoneally in mice and per os in rats, against seizures induced by maximal electroshock (MES) and pentylene-tetrazole (scMet). Neurologic deficity was evaluated by the rotarod test. The compounds were prepared to determine the relationship between the 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives' structures and anticonvulsant activity. Several of these compounds showed significant anticonvulsant activity. Compounds 43 and 45 were the most active of the series against MES-induced seizures with ED50 values of 8.7 and 7.6 mg/kg, respectively. Compound 45 displayed good protection against MES-induced seizures and low toxicity in rats with an oral ED50 of 18.6 mg/kg and a protective index (PI = TD50/ED50) of 1 receptors with nanomolar affinities.

Pharmacomodulation of 7-(-2-methylene-butyryl)- 2,3-dihydro-benzoxazin-[1,4]-3-one structure and normolipemic activity

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