54944-19-3Relevant academic research and scientific papers
Preparation of alkyl- and aryl-aminomethylphosphinic acids
Berte-Verrando, Sylvie,Nief, Francois,Patois, Carl,Savignac, Philippe
, p. 2045 - 2048 (1995)
Diethyl chloromethylphosphonate upon successive treatment with POCl3 and Grignard reagents (RMgX) gave alkyl(chloromethyl)phosphinates.Phenyl(chloromethyl)phosphinate was prepared by deuterolysis of the α-silylated α-phosphonylated ca
New syntheses of 1-chloroalkylphosphinates
Morise, Xavier,Savignac, Philippe,Denis, Jean-Marc
, p. 2179 - 2185 (2007/10/03)
Different approaches to the synthesis of 1-chloroalkylphosphinates are described. Initially, we tried to extend a reaction described by Kabachnik for the preparation of chloromethylphosphinic acid chlorides [R1(Cl)P(O)CH2Cl] to C-substituted derivatives. We also considered the possibility of synthesizing the title compounds by routes already described for the formation of diethyl 1-chloroalkylphosphonates. Although these methods have allowed us to obtain several of the desired phosphinates, they suffer from limitations that restrict their synthetic applications. Finally, we have developed a more general approach that allows the formation of a wide range of phosphinates. It involves a selective P-C bond formation by reaction of MeMgCl and PhMgCl with phosphonochloridates, which are prepared by P-chlorination of 1-chloroalkylphosphonates.
