54950-12-8

Usage

Structure

Pyrimidine derivative with a pyridine ring attached to the 6th position of the pyrimidine ring

Functional Groups

Amino group ( \textNH2 ) at the 2nd position of the pyridine ring
Carbonyl group ( \textC=O ) at the 4th position of the pyrimidine ring

Common Use

Building block for synthesizing various drug molecules

Biological Activities

Studied for potential biological activities in the pharmaceutical industry.

Upstream product

• 26377-17-3 ethyl 3-oxo-3-(4-pyridyl)propanoate 
• 593-85-1 diguanidine carbonate 
• 113-00-8 guanidine nitrate 
• 124-46-9 guanidine hydrogen carbonate 
• 55-22-1 pyridine-4-carboxylic acid 

Relevant academic research and scientific papers

HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS

The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-kinase.

Rho-kinase inhibitors

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., c

PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS

The invention relates to the phenylaminopyrimidines of formula (I), wherein A, D, R1, R2, R3 and R4 are defined as in the description. The invention also relates to methods for producing said phenylaminopyrimidines and to their use for producing drugs for the treatment and/or the prophylaxis of diseases, especially cardiovascular diseases.

PYRIMIDONE DERIVATIVES

A pyrimidone derivative represented by the formula (I) or a salts thereof: wherein R1 represents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; R2 represents a hydrogen atom, hydro