549501-27-1

Upstream product

• 100-39-0 benzyl bromide 
• 549501-23-7 (3R,4R,5R,6R)-3-Azido-6-azidomethyl-4,5-bis-benzyloxy-2-phenylsulfanyl-tetrahydro-pyran 
• 632330-83-7 Toluene-4-sulfonic acid (2R,3S,4R,5R)-5-azido-3,4-dihydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethyl ester 
• 632330-84-8 phenyl 2,6-diazido-2,6-dideoxy-1-thio-α/β-D-glucopyranoside 
• 183875-22-1 phenyl 2-azido-2-deoxy-3,4,6-tri-O-acetyl-1-thio-α/β-D-glucopyranoside 
• 202462-37-1 phenyl 2-azido-2-deoxy-1-thio-α/β-D-glucopyranoside 
• 171032-74-9 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-D-glucopyranose 
• 549501-26-0 5,6-di-O-acetyl-3',4'-di-O-benzyl-1,3,2',3'-tetraazidoneamine 

Downstream Products

• 549501-35-1 (1S,2R,3R,4S,6R)-4,6-Diamino-3-((2R,3R,4R,5R,6R)-3-amino-6-aminomethyl-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy)-cyclohexane-1,2-diol 
• 860795-31-9 5,6-di-O-benzoyl-3',4'-di-O-benzyl-1,3,2',3'-tetraazidoneamine 
• 1220530-38-0 C₃₃H₄₃N₁₃O₇ 
• 1220530-39-1 C₄₀H₅₆N₁₄O₈ 
• 3947-65-7 neomycin A 
• 860795-47-7 6-O-(4-azido-2,3-di-O-benzyl-4,6-dideoxy-α-D-glucopyranosyl)-3',4'-di-O-benzyl-1-N-[(S)-4-(benzyloxycarbonylamino)-2-hydroxybutanoyl]-3,2',3'-triazidoneamine 
• 860795-48-8 6-O-(3-azido-2-O-benzyl-3,6-dideoxy-α-D-glucopyranosyl)-3',4'-di-O-benzyl-1-N-[(S)-4-(benzyloxycarbonylamino)-2-hydroxybutanoyl]-3,2',3'-triazidoneamine 
• 860795-53-5 5-O-(4-azido-3,6-dideoxy-β-D-glucopyranosyl)-3',4'-di-O-benzyl-1-N-[(S)-4-(benzyloxycarbonylamino)-2-hydroxybutanoyl]-3,2',3'-triazidoneamine 
• 860795-45-5 6-O-(4-azido-2,3-di-O-benzyl-4,6-dideoxy-α-D-glucopyranosyl)-3',4'-di-O-benzyl-1-N-tert-butoxycarbonyl-3,2',3'-triazidoneamine 

Relevant academic research and scientific papers

Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues

Novel fungicides are urgently needed. It was recently reported that the attachment of an octyl group at the O-4″ position of kanamycin B converts this antibacterial aminoglycoside into a novel antifungal agent. To elucidate the structure-activity relation

Tuning the regioselectivity of the staudinger reaction for the facile synthesis of kanamycin and neomycin class antibiotics with N-1 modification

(Chemical Equation Presented) A novel method for achieving the desired regioselective reduction of the N-1 azido group on a tetraazidoneamine has been developed that leads to the synthesis of both kanamycin and neomycin class antibiotics bearing N-1 modif

AMINOGLYCOSIDE ANTIBIOTICS AND METHODS OF USING SAME

The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses antibiotic activity and are not susceptible to development of resistant bacterial strains. The present invention also relates to methods of treatment and pharmaceutical compositions that utilize or comprise one or more of aminoglycoside compounds provided by the invention.

Synthesis of (+),(-)-neamine and their positional isomers as potential antibiotics

The syntheses of (+)-neamine 1, (-)-neamine ent-1 and their positional isomers 2, 3, ent-2 and ent-3 are reported as potential new scaffolds for novel aminoglycoside antibiotics. These isomers exhibit similar inhibitory activities, as shown using an in vitro translation assay. A simple model is proposed to explain this lack of stereospecific binding to the ribosomal RNA.