549505-58-0

Upstream product

• 585-71-7 (1-bromoethyl)benzne 
• 452056-98-3 4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamine 
• 549505-65-9 ML 3403 
• 74-88-4 methyl iodide 
• 695-34-1 2-Amino-4-methylpyridine 
• 549505-57-9 N-{4-[2-cyano-2-(4-fluoro-phenyl)-1-hydroxy-vinyl]-pyridin-2-yl}-acetamide 
• 452056-82-5 N-{4-[2-(4-fluorophenyl)-2-hydroxyliminoacetyl]pyridin-2-yl}acetamide 
• 452056-81-4 N-{4-[2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide 
• 452056-80-3 1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone 
• 452056-88-1 N-{4-[4-(4-fluorophenyl)-1-methyl-2-thioxo-2,3-dihydro-1H-imidazol-5-yl]pyridin-2-yl}acetamide 
• 452056-93-8 N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide 
• 452056-83-6 N-{4-[5-(4-fluorophenyl)-1-oxy-3-methyl-3H-imidazol-4-yl]pyridin-2-yl}acetamide 

Relevant academic research and scientific papers

2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS

The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the

Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole derivatives by regiospecific synthesis, GC/MS, and 1H NMR

The regiospecific synthesis of 2a (Scheme 3), a novel and potent pyridinyl imidazole inhibitor of p38 MAP (mitogen-activated protein) kinase, and the regioselective preparation of its regioisomer 2b (Scheme 4) are described. Chromatographic and spectroscopic data are presented, which in this class of compounds allow the unambiguous identification of regioisomers prepared by a nonregiospecific synthetic strategy. Biological data demonstrating the importance of the correct regiochemistry for inhibition of p38 are given.