54951-54-1

Basic information

• Product Name: N-[4-[(dimethylamino)sulphonyl]phenyl]acetamide
• Synonyms: N-[4-[(dimethylamino)sulphonyl]phenyl]acetamide;4'-(N,N-Dimethylsulfamoyl)acetanilide;N-[4-(Dimethylsulfamoyl)phenyl]acetamide;N-[4-(dimethylamino-4-ylsulfonyl)phenyl]acetamide;N-(4-(N,N-dimethylsulfamoyl)phenyl)acetamide
• CAS NO: 54951-54-1
• Molecular Formula: C₁₀H₁₄N₂O₃S
• Molecular Weight: 242.29476
• EINECS: 259-408-4
• Mol File: 54951-54-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 103-130 °C
• Appearance: /
• Density: 1.288g/cm³
• Refractive Index: 1.57
• PKA: 14.39±0.70(Predicted)
• CAS DataBase Reference: N-[4-[(dimethylamino)sulphonyl]phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-[(dimethylamino)sulphonyl]phenyl]acetamide(54951-54-1)
• EPA Substance Registry System: N-[4-[(dimethylamino)sulphonyl]phenyl]acetamide(54951-54-1)

Safety Data

• Hazardous Substances Data: 54951-54-1(Hazardous Substances Data)

Usage

General Description

N-[4-[(dimethylamino)sulphonyl]phenyl]acetamide is a chemical compound with the molecular formula C10H14N2O3S. It is a derivative of acetic acid and contains a phenyl group with a sulfonyl and dimethylamino substituent. N-[4-[(dimethylamino)sulphonyl]phenyl]acetamide is used in the synthesis of pharmaceuticals and organic compounds. N-[4-[(dimethylamino)sulphonyl]phenyl]acetamide is also known for its potential use as a precursor in the preparation of various bioactive molecules. Additionally, it has been studied for its potential biological activities and has shown promising results in certain medicinal applications.

InChI:InChI=1/C10H14N2O3S/c1-8(13)11-9-4-6-10(7-5-9)16(14,15)12(2)3/h4-7H,1-3H3,(H,11,13)

Upstream product

• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 2858-20-0 5-chloro-2,6-dimethyl-pyrimidin-4-ylamine 
• 103-84-4 Acetanilid 
• 62-53-3 aniline 
• 77-78-1 dimethyl sulfate 
• 121-61-9 p-acetylaminobenzenesulfonamide 
• 124-40-3 dimethyl amine 

Downstream Products

• 515-67-3 N-sulfanilyl-sulfanilic acid dimethylamide 
• 100318-60-3 N-allyl-N'-(4-dimethylsulfamoyl-phenyl)-thiourea 
• 93345-14-3 N-(N-acetyl-sulfanilyl)-sulfanilic acid dimethylamide 
• 167156-25-4 N-[4-(N,N-dimethylamino)sulfonylphenyl]-2-hydroxy-2-trifluoromethylpropionamide 
• 1709-59-7 4-amino-N,N-dimethylbenzenesulphonamide 

Relevant articles and documents

Effect of photodynamic antibacterial chemotherapy combined with antibiotics on Gram-positive and gram-negative bacteria

The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In the present study, the effect of PACT using a photosensitizer Rose Bengal alone and in combination with antibiotics including methicillin and derivatives of sulfanilamide synthesized by us was tested against antibiotic-sensitive and antibiotic-resistant clinical isolates of Gram-positive S. aureus and Gram-negative P. aeruginosa. Antibiotic-sensitive and resistant strains of P. aeruginosa were eradicated by Rose Bengal under illumination and by sulfanilamide but were not inhibited by new sulfanilamide derivatives. No increase in sensitivity of P. aeruginosa cells to sulfanilamide was observed upon a combination of Rose Bengal and sulfanilamide under illumination. All tested S. aureus strains (MSSA and MRSA) were effectively inhibited by PACT. When treated with sub-MIC concentrations of Rose Bengal under illumination, the minimum inhibitory concentrations (MIC) of methicillin decreased significantly for MSSA and MRSA strains. In some cases, antibiotic sensitivity of resistant strains can be restored by combining antibiotics with PACT.

Azo coupling of o- and p-(dialkylaminosulfonyl)benzene-diazonium salts with 7-acetylamino-4-hydroxynaphthalene-2-sulfonic acid in citrate-phosphate buffer solution

Dependences of the partial rate constants for azo coupling of o-(dialkylaminosulfonyl)benzene-diazonium salts with 7-acetylamino-4-hydroxynaphthalene-2-sulfonic acid (N-Acetyl-I-acid) on the fraction of the dianionic form of the latter indicate considerable steric hindrances to the second stage of the reaction. Ionization of the hydroxy group of N-acetyl-I-acid gives rise to additional electrostatic repulsion at the stage of formation of the σ complex, which reduces the rate of azo coupling at the 3-position of orthanilic acid.

Studies of the synthesis of sulfonamides: An improved preparation of Sulfaclomid

-