54985-29-4Relevant articles and documents
Distal Alkenyl C-H Functionalization via the Palladium/Norbornene Cooperative Catalysis
Dong, Guangbin,Fatuzzo, Nina,Wu, Zhao
, p. 2715 - 2720 (2020)
A distal-selective alkenyl C-H arylation method is reported through a directed palladium/norbornene (Pd/NBE) cooperative catalysis. The key is to use an appropriate combination of the directing group and the NBE cocatalyst. A range of acyclic and cyclic c
The biogenic amine transporter activity of vinylogous amphetamine analogs
Decker, Ann M.,Partilla, John S.,Baumann, Michael H.,Rothman, Richard B.,Blough, Bruce E.
supporting information, p. 1657 - 1663 (2016/08/24)
A series of vinylogous amphetamine analogs was synthesized and examined for their activity at biogenic amine transporters and serotonin-2 receptor (5-HT2) subtypes. (1S,3E)-1-Methyl-4-phenyl-but-3-enylamine (S-6) is a potent dual dopamine/serotonin (DA/5-HT) releaser with no activity at 5-HT2 receptors. This unique profile of actions suggests that analog S-6 is a viable lead compound for identifying new structural classes of DA/5-HT releasers with therapeutic benefit and reduced abuse liability.