54986-96-8

Basic information

• Product Name: 2-phenyl-thiazole-4,5-dicarboxylic acid diethyl ester
• Synonyms: 2-phenyl-thiazole-4,5-dicarboxylic acid diethyl ester
• CAS NO: 54986-96-8
• Molecular Weight: 305.354
• Mol File: 54986-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-phenyl-thiazole-4,5-dicarboxylic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-thiazole-4,5-dicarboxylic acid diethyl ester(54986-96-8)
• EPA Substance Registry System: 2-phenyl-thiazole-4,5-dicarboxylic acid diethyl ester(54986-96-8)

Safety Data

• Hazardous Substances Data: 54986-96-8(Hazardous Substances Data)

Upstream product

• 5445-93-2 2-amino-4,5-bis(ethoxycarbonyl)thiazole 
• 71-43-2 benzene 
• 2227-79-4 benzenecarbothioamide 
• 34034-87-2 diethyl 3-chloro-2-oxosuccinate 

Downstream Products

• 30865-67-9 2-phenylthiazole-4,5-dicarbohydrazide 
• 38707-83-4 2-phenyl-thiazole-4,5-dicarboxylic acid 
• 7403-85-2 2-phenyl-thiazole-4,5-dicarboxylic acid diamide 
• 164023-48-7 2-phenyl-thiazole-4,5-dicarboxylic acid dihydrazide 
• 92126-34-6 2-phenyl-4,5-bis(hydroxymethyl)thiazole 
• 7113-10-2 2-phenyl-1,3-thiazole-4-carboxylic acid 
• 92126-35-7 2-phenyl-4,5-bis(hydroxymethyl)thiazole bis(methylcarbamate) 

Relevant articles and documents

Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents

A series of bis(hydroxymethyl)-substituted heterocycles were synthesized and converted to the corresponding bis(methylcarbamate) derivatives. The heterocyclic systems studied were based on 2-phenyl-3-methylfuran, 1-phenylpyrazole, 1-phenyl-5-methylpyrazole, 1-phenyl-5-methylthiopene, 1-phenyl-1,2,3-triazole, 3-phenylisoxazole, 3-phenylisothiazole, 2-phenylthiazole, and 2-phenyloxazole. None of the bis(carbamates) prepared was active against murine P388 lymphocytic leukemia. Pyrrole bis(carbamate), which exhibited antileukemic activity, also showed reactivity toward 4-(p-nitrobenzyl)pyridine while the inactive bis(carbamates) were unreactive in the 4-(p-nitrobenzyl)pyridine assay.