34034-87-2

Basic information

• Product Name: 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER
• Synonyms: DIETHYL 2-CHLORO-3-OXOSUCCINATE;2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER;Chlorooxalacetic Acid Diethyl Ester;Diethyl Chlorooxalacetate;Diethyl 2-chloro-3-oxobutane-1,4-dioate;diethyl 2-chloro-3-oxobutanedioate;Diethyl 2-chlorooxalacetate, technical, 90%;2-Chloro-3-oxo butanedioic acid 1,4-diethyl ester
• CAS NO: 34034-87-2
• Molecular Formula: C₈H₁₁ClO₅
• Molecular Weight: 222.62
• EINECS: 200-589-5
• Mol File: 34034-87-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 130 °C / 9mmHg
• Flash Point: 108℃
• Appearance: /
• Density: 1.23
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.4480
• Storage Temp.: 0-10°C
• PKA: 5.24±0.46(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER(34034-87-2)
• EPA Substance Registry System: 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER(34034-87-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 34034-87-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-oxo-succinic acid diethyl ester, also known as ethyl 2-chloro-3-oxobutanedioate, is a chemical compound with the molecular formula C8H11ClO5. It is an ester derivative of succinic acid and has a chlorine atom and a ketone functional group attached to the succinic acid backbone. 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various drugs and bioactive compounds. It is a colorless liquid with a fruity odor and is slightly soluble in water but readily soluble in organic solvents. Its versatile reactivity and potential applications make it a valuable compound in various chemical and pharmaceutical industries.

InChI:InChI=1/C8H11ClO5/c1-3-13-7(11)5(9)6(10)8(12)14-4-2/h5H,3-4H2,1-2H3

Upstream product

• 60-29-7 diethyl ether 
• 141-52-6 sodium ethanolate 
• 105-39-5 chloroacetic acid ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 7647-01-0 hydrogenchloride 
• 56475-23-1 2,2-diethoxy-3-chloro-succinic acid diethyl ester 
• 141-78-6 ethyl acetate 
• 108-56-5 diethyl oxaloacetate 

Downstream Products

• 54986-96-8 2-phenyl-thiazole-4,5-dicarboxylic acid diethyl ester 
• 855463-51-3 3-chloro-7-hydroxy-6-methoxy-2-oxo-2H-chromene-4-carboxylic acid ethyl ester 
• 101113-39-7 2-(4-sulfamoyl-phenyl)-thiazole-4,5-dicarboxylic acid diethyl ester 
• 854473-54-4 2-[(N-acetyl-sulfanilyl)-amino]-thiazole-4,5-dicarboxylic acid diethyl ester 
• 3681-17-2 3-chloropyruvic acid 
• 5330-70-1 pyruvic acid phenylhydrazone 
• 5445-93-2 2-amino-4,5-bis(ethoxycarbonyl)thiazole 
• 60084-06-2 2-(5-benzoyloxymethyl-furan-2-yl)-thiazole-4,5-dicarboxylic acid diethyl ester 
• 471-46-5 Oxalamide 
• 144-62-7 oxalic acid 
• 79-11-8 chloroacetic acid 
• 144689-94-1 diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate 
• 444615-63-8 diethyl 2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4,5-dicarboxylate 
• 105151-39-1 diethyl 5-ethyl-2,3-pyridinedicarboxylate 

Relevant articles and documents

Dual Photoredox/Cobaloxime Catalysis for Cross-Dehydrogenative α-Heteroarylation of Amines

We report a dual-catalytic platform for the cross-dehydrogenative-coupling between (benzo-)thiazoles and amines which combines low loadings of an iridium photoredox catalyst and a cobaloxime catalyst under blue light irradiation. This transformation occurs without stoichiometric oxidants, giving products in moderate to excellent yields. DFT calculations support the key role of Co(II) for rearomatization of the radical-addition intermediate to generate the product.

A 4 - (1 - hydroxy -1 - methyl ethyl) -2 - propyl - 1H - imidazole -5 - carboxylic acid ethyl ester preparation method

The invention relates to a preparation method of 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester and belongs to the technical field of medicament synthesis. In order to solve the problems of long reaction route, heavy pollution and low yield in the prior art, the invention provides a preparation method of 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester. The method comprises the following steps: in the presence of organic alkali, enabling a raw material alpha-chlorinated oxaloacetic acid diethyl ester to react with butanimidamide or acidic salt of butanimidamide to obtain an intermediate compound, then enabling the intermediate compound to perform Grignard reaction with CH3MgX to obtain 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester, wherein X in CH3MgX is halogen. The method disclosed by the invention has the advantages of short reaction route, less pollution, mild reaction condition and high yield.

Improved synthesis of thienothiazole and its utility in developing polymers for photovoltaics

In response to the structural and electronic limitations of the popular benzo[1,2-b:4,5-b′]dithiophene-thieno[3,4-b]thiophene (PBnDT-TT) polymer series, this study explores the design and synthesis of a thienothiazole (TTz) moiety. The synthesis of TTz was streamlined down to four high-yielding steps, resulting in the new polymer PBnDT-TTz for organic solar cells. By incorporating TTz, a nitrogen is directly introduced into the polymer backbone which tunes the HOMO level and eliminates the reliance on external substituents. Compared to its TT analogue, PBnDT-TTz exhibits the same HOMO level of -5.06 eV and the same Voc of 0.69 eV, yet a higher power conversion efficiency of 2.5%. These promising results demonstrate the benefits of backbone modification and the great potential of TTz in the design of new polymers for organic photovoltaics.