55023-35-3

Usage

Uses

Used in Pharmaceutical Research and Development:
7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one serves as a crucial building block in the pharmaceutical industry, utilized for the development of new drugs. Its unique molecular structure and biological activities make it a valuable asset in the design and synthesis of innovative therapeutic agents.
Used in Medicinal Chemistry:
In the realm of medicinal chemistry, 7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one is employed as a key component in the synthesis of compounds with potential therapeutic applications. Its versatility in chemical reactions allows for the exploration of various chemical modifications to enhance its pharmacological properties.
Used in Disease Treatment:
Given its wide range of biological activities, 7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one holds promise for the treatment of various diseases. Its potential applications span across different therapeutic areas, offering new avenues for drug discovery and development.
Used in Chemical and Pharmacological Studies:
The unique structure and properties of 7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one make it an intriguing subject for further chemical and pharmacological research. Its exploration can lead to a deeper understanding of its mechanisms of action and the discovery of new therapeutic targets.

Upstream product

• 52505-56-3 ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate 
• 77287-34-4 formamide 
• 3473-63-0 formamidine acetic acid 
• 149-73-5 trimethyl orthoformate 
• 67795-42-0 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 
• 175847-74-2 ethyl 3-ethoxyetyleneamino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate 

Downstream Products

• 548430-99-5 Diisopropyl-phosphoramidous acid (S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(7,9-dimethyl-4-oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)-propyl ester 2-cyano-ethyl ester 
• 548430-98-4 3-{(S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-butyl}-7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one 
• 753479-87-7 3-{(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one 
• 912576-65-9 3-[(2,3-di-p-toluenesulfonyloxy)propyl]-7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one 
• 912576-53-5 7,9-dimethyl-3-[[2-(p-tolylsulfonyloxy)ethoxy]methyl]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one 
• 918440-64-9 7,9-dimethyl-3-(2'-p-tolylsulfonyl)-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one 
• 722455-16-5 3-allyl-7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one 
• 72792-87-1 3-benzyl-7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one 

Relevant academic research and scientific papers

Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2

This Letter details our efforts to develop novel tricyclic M4 PAM scaffolds with improved pharmacological properties. This endeavor involved a “tie-back” strategy to replace the 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide core which lead to the discovery of two novel tricyclic cores: a 7,9-dimethylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine core and 2,4-dimethylthieno[2,3-b:5,4-c′]dipyridine core. Both tricyclic cores displayed low nanomolar potency against the human M4 receptor.

Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors

Cdc7 kinase plays a critical role in the regulation of DNA replication in eukaryotic cells and has been proposed as a target for cancer therapy. We have identified a class of Cdc7/Dbf4 inhibitors with a pyrido-thieno-pyrimidine core structure. Synthesis o

Synthesis of some new pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones and pyrido[3′,2′: 4,5]thieno[2,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives

2,3-Disubstituted-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4( 3H) -ones 8a-8c, 9a-9c were obtained by treatment of pyrido[3′,2′:4,5]thieno[3,2-d][1,3]oxazin-4(3H)-one derivative 3, 3-diacetylamino-thieno[2,3-b]pyridine derivative 5 and 3-ethoxymethyleneaminothieno[2,3-b]pyridine derivative 7a with appropriate amines, respectively. Condensation of compounds 8b, 9b with appropriate α-chlorocarbonyl compounds gave the corresponding 3-substituted carbonylmethylene-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one derivatives 13a-d. 3-N-Substituted-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones 15a,b, 16a,b and 18a,b were also obtained by cyclization of carbohydrazide 14 with different reagents under a variety of conditions. On the other hand, cyclization of 3-amino-4-imino-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones 21a,b with appropriate orthoesters afforded the corresponding 3,5-dialkyl-pyrido[3′,2′:4,5]thieno[2,3-e]-1,2,4-triazolo[1,5-c] pyrimidines 22a-f.