7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one

Base Information

• Chemical Name: 7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one
• CAS No.: 55023-35-3
• Molecular Formula: C11H9N3OS
• Molecular Weight: 231.27
• Hs Code.: 2934999090
• Mol file: 55023-35-3.mol

Synonyms:7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-ol;7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one;7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidine-4(1H)-one;7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one;pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-ol,7,9-dimethyl;7,9-Dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one;7,9-Dimethyl-pyrido<3',2'-4,5>thieno<3,2-d>pyrimid-4-on;

Chemical Property of 7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one

Chemical Property:

• Melting Point: 340℃
• Boiling Point: 489.8±40.0 °C(Predicted)
• PKA: 9.68±0.20(Predicted)
• Flash Point: 222.2oC
• PSA: 86.88000
• Density: 1.55
• LogP: 2.14960

Purity/Quality:

98%Min ^*data from raw suppliers

7,9-Dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one

There total 7 articles about 7,9-Dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 3-ethoxyetyleneamino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate (175847-74-2) → 7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidine-4(1H)-one (55023-35-3)

Guidance literature:

With ammonia; In ethanol; for 3h; Heating;

DOI:10.1002/jccs.200100172

Reference yield: 82.0%

ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate (52505-56-3) + formamide (77287-34-4,77287-35-5,60100-09-6) → 7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidine-4(1H)-one (55023-35-3)

Guidance literature:

for 24h; Heating;

DOI:10.1002/jccs.200100172

Reference yield:

ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate (52505-56-3) + formamidine acetic acid (3473-63-0) → 7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one (55023-35-3)

Guidance literature:

ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate; formamidine acetic acid; In formamide; at 150 ℃; for 4h;

formamidine acetic acid; In formamide; at 150 ℃; for 5h;

DOI:10.1016/j.bmcl.2021.128416

upstream raw materials:

ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate

formamide

ethyl 3-ethoxyetyleneamino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate

trimethyl orthoformate

Downstream raw materials:

3-benzyl-7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one

3-allyl-7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

7,9-dimethyl-3-(2'-p-tolylsulfonyl)-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

7,9-dimethyl-3-[[2-(p-tolylsulfonyloxy)ethoxy]methyl]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one