550355-42-5Relevant academic research and scientific papers
Selective radical amination of aldehydic C(sp2)-H bonds with fluoroaryl azides via Co(ii)-based metalloradical catalysis: Synthesis of N-fluoroaryl amides from aldehydes under neutral and nonoxidative conditions
Jin, Li-Mei,Lu, Hongjian,Cui, Yuan,Lizardi, Christopher L.,Arzua, Thiago N.,Wojtas, Lukasz,Cui, Xin,Zhang, X. Peter
, p. 2422 - 2427 (2014)
The Co(ii) complex of the D2h-symmetric amidoporphyrin 3,5-DitBu-IbuPhyrin, [Co(P1)], has proven to be an effective metalloradical catalyst for intermolecular amination of C(sp2)-H bonds of aldehydes with fluoroaryl azides. The [Co(P1)]-catalyzed process can employ aldehydes as the limiting reagents and operate under neutral and nonoxidative conditions, generating nitrogen gas as the only byproduct. The metalloradical aldehydic C-H amination is suitable for different combinations of aldehydes and fluoroaryl azides, producing the corresponding N-fluoroaryl amides in good to excellent yields. A series of mechanistic studies support a stepwise radical mechanism for the Co(ii)-catalyzed intermolecular C-H amination. This journal is the Partner Organisations 2014.
