5504-50-7

Upstream product

• 5281-18-5 benzaldehyde, hydrazone 
• 501-53-1 benzyl chloroformate 
• 100-52-7 benzaldehyde 
• 5331-43-1 N-benzyloxycarbonyl-hydrazine 
• 135942-02-8 N^α-benzyl-N^α-Z hydrazine 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 97411-43-3 Benzaldehyde dibenzyloxycarbonylhydrazone 
• 135942-02-8 N^α-benzyl-N^α-Z hydrazine 
• 5501-13-3 N-Benzyl-N-benzyloxycarbonyl-N'-benzyliden-hydrazin 
• 1043436-32-3 C₁₉H₂₀N₂O₄ 
• 1043436-29-8 C₁₆H₁₆N₂O₂ 

Relevant academic research and scientific papers

Oxidative Dehydrogenative [3+3] Annulation of Benzylhydrazines with Aziridines Leading to Tetrahydrotriazines

Oxidative dehydrogenative [3+3] annulation of benzylhydrazines with N-sulfonylaziridines is described. A series of complex tetrahydro-1,2,4-triazines were produced under mild reaction conditions.

Gold-catalyzed three-component spirocyclization: A one-pot approach to functionalized pyrazolidines

An efficient, highly atom economic synthesis of hitherto unknown spirocyclic pyrazolidines in a one-pot process was developed. The gold-catalyzed three-component coupling of alkynols, hydrazines and aldehydes or ketones likely proceeds via cycloisomerization of the alkynol to an exocyclic enol ether and subsequent [3 + 2]-cycloaddition of an azomethine ylide. A library of 29 derivatives with a wide range of functional groups was synthesized in up to 97% yield. With this new method, every position in the final product can be substituted which renders the method ideal for applications in combinatorial or medicinal chemistry.

I2 mediated synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones via sequential condensation/oxidative cyclization and rearrangement

A simple and efficient iodine-assisted protocol for the synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones has been developed. The reaction involves a sequential condensation followed by tandem oxidative cyclization and rearrangement of

Peptidyl and azapeptidyl methylketones as substrate analog inhibitors of papin and cathepsin B

Peptidyl methylketones containing Phe, Tyr, Tyr(I), Tyr(I2), Leu and Ile in P2 were synthesized and tested as substrate analog revesible of papain and bovine spleen cathepsin B.The most effective cathepsin B inhibitor contained Tyr(I2) and displayed an inhibition constant of 4.7 μM at pH 6.8 and 25 deg C, while Leu or Ile gave practically inert analogs.Replacement of the amino acids in P2 with the analogues α-azaamino acids, as well as the glycine in P1 with α-azaglycine, led to complete loss of inhibiting activity.Introducing alkoxy substituents at themethyl adjacent to the ketone group generally resulted in more effective inhibitors, with inhibition constants in the micromolar range for both papin and cathepsin B. - Keywords: enzyme inhibiting activity; cysteine proptease; slow binding; peptidyl methylketone; azapeptidyl methylketone; papain; cathepsin B

Sodium cyanoborohydride reduction of (benzyloxycarbonyl)- and (tert-butoxycarbonyl)hydrazones

(Benzyloxycarbonyl)- and (tert-butoxycarbonyl)hydrazones are easily reduced by sodium cyanoborohydride in acidic medium. The method is an alternative to catalytic hydrogenation and allows ready access to both N-benzyloxycarbonyl and N-tert-butoxycarbonyl

ORGANISCHE PHOSPHORVERBINDUNGEN 84. HERSTELLUNG, EIGENSCHAFTEN UND BIOLOGISCHE WIRKUNG VON HYDRAZINOMETHYL-PHOSPHON- UND -PHOSPHINSAEUREN UND DERIVATEN

The synthesis and the chemical, physical, spectral and biological properties of hydrazinomethyl-phosphonic- and -phosphinic acids and derivatives, i.e. hydrazino-N-alkoxycarbonyl-N'-alkylene-O,O-dialkoxyphosphonates, 2, -phosphinates, 3, hydrazinomethyl-O

Synthesis of New N-Aminoaziridine Derivatives by the Addition of Dibenzyloxycarbonylaminonitrene to Olefins

In order to study the ring expansion of N-aminoaziridines into N-amino-5-membered heterocycles, N-(dibenzyloxycarbonylamino)aziridines were synthesized.N,N-Dibenzyloxycarbonylhydrazine was prepared.It was then oxidized with lead tetraacetate to a new diacylaminonitrene.This nitrene was added to various olefins to give the corresponding N-protected aminoaziridines.Cleavage of the protecting groups was realized for one example.