55075-24-6

Upstream product

• 106-44-5 p-cresol 
• 100-52-7 benzaldehyde 
• 124-40-3 dimethyl amine 

Downstream Products

• 55075-31-5 2-[hydroxy(phenyl)methyl]-4-methylphenol 
• 85628-71-3 1-Methoxy-1-phenyl-1-<(2-hydroxy-5-methyl)-phenyl>-methan 
• 55075-32-6 1-Ethoxy-1-phenyl-1-<(2-hydroxy-5-methyl)-phenyl>-methan 
• 85628-72-4 1-Isopropyl-1-phenyl-1-<(2-hydroxy-5-methyl)-phenyl>-methan 

Relevant academic research and scientific papers

Br?nsted-Acid-Mediated Divergent Reactions of Betti Bases with Indoles: An Approach to Chromeno[2,3-b]indoles through Intramolecular Dehydrogenative C2-Alkoxylation of Indole

Divergent reactions of various 1-(aminoalkyl)naphthols and 2-(aminoalkyl)phenols (commonly known as Betti bases) with indoles under Br?nsted acid catalysis is reported. With the reaction strategies, one can efficiently synthesize important indole derivatives such as 3-(α,α-diarylmethyl)indoles and chromeno[2,3-b]indoles. Furthermore, we disclose here a new C–C bond-cleavage reaction, in which naphthol and phenol behave as leaving groups to produce diarylmethanes. Inexpensive reagents such as p-toluenesulfonic acid monohydrate and molecular iodine are used to catalyze the reactions. No metal catalyst is required. The starting material of the reactions, Betti bases, are easily prepared from a three-component reaction of naphthol/phenol, aldehydes, and secondary amines. The mechanisms for the reactions are established through some control experiments. Quinone methide is the key intermediate for all the reactions reported herein.

CAN-catalyzed microwave promoted reaction of indole with Betti bases under solvent-free condition and evaluation of antibacterial activity of the products

CAN-catalyzed reaction of Betti bases with indoles under microwave irradiation gives 3-(α,α-diarylmethyl)indoles. Better yield of the products, especially when one of the aryl ring is phenol were achieved. The reaction is performed in solvent-free condition. The antibacterial studies of the synthesized compounds were performed and some of the compounds showed good activity against Methicillin-resistant Staphylococcus aureus bacteria.