55121-95-4Relevant academic research and scientific papers
Synthesis and in vitro cytotoxic evaluation of 7-chloro-4-anilino-quinoline amide derivatives
Trung Hieu, Bui,Thuy, Vu Thu,Tien, Hoang Xuan,Vu, Tran Khac
, p. 4453 - 4456 (2013/06/27)
A series of new amide derivatives of 4-anilino-quinoline have been synthesized and evaluated in vitro cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1) and human breast cancer (MCF-7). Compound 5g was found to be most potent cytotoxic activity against HepG2 and MCF-7 cell lines with IC50 values of 2.09 and 4.63 μg/mL, respectively. Compound 5e exhibited significant cytotoxic activity against three cell lines with IC50 values ranging from 5-10 μg/mL.
Synthesis of 4-(4-Substituted arylamino)-7-chloroquinolines and Their Antimalarial and Antifilarial Activities
Chauhan, P. M. S.,Sharma, S.,Bhakuni, D. S.
, p. 828 - 831 (2007/10/02)
Several 4-(4-substituted arylamino)-7-chloroquinolines (8-10, 11-14 and 15-22) and 7-chloro 4-(S-substituted quinoline) 28 have been synthesized and tested for antimalarial and antifilarial activities.The compounds (8-10, 12-15 and 17-24) and 28, however,
