55137-68-3

Upstream product

• 4755-72-0 Chloro-phenyl-acetic acid 
• 79-37-8 oxalyl dichloride 
• 7021-09-2 rac-methoxyphenylacetic acid 
• 26164-26-1 (S)-2-methoxy-2-phenylacetic acid 
• 166180-82-1 (R S)-2-amino-3-[3-ethoxy-5-(2-thienyl)isoxazol-4-yl]propionic acid 

Downstream Products

• 35822-65-2 O-Methylmandelsaeure-p-chlorphenylester 
• 74613-74-4 O-Methylmandelsaeure-2,4-dichlorphenylester 
• 99071-90-6 2-methoxy-2-phenylacetyldiazomethane 
• 7472-78-8 2-methoxy-N-phenyl-2-phenylacetamide 
• 3962-43-4 1,2-diphenyl-1,2-dimethoxy ethane, meso 
• 119702-44-2 1-(Methoxy-phenyl-methyl)-cyclohexanol 
• 7476-63-3 (+/-)-2-methoxy-2-phenylacetamide 
• 100-52-7 benzaldehyde 
• 74-87-3 methylene chloride 
• 1146137-34-9 2-methoxy-N-methyl-N,2-diphenylacetamide 
• 1040730-81-1 N-(2-chlorophenyl)-2-methoxy-N-methyl-2-phenylacetic acid amide 
• 1219027-90-3 (+/-)-1-ethylpropyl α-methoxyphenylacetate 
• 1301714-92-0 C₂₀H₂₁NO₄ 
• 1301715-06-9 C₁₈H₁₇NO₄ 

Relevant academic research and scientific papers

Functionalization of α-C(sp3)?H Bonds in Amides Using Radical Translocating Arylating Groups

α-C?H arylation of N-alkylamides using 2-iodoarylsulfonyl radical translocating arylating (RTA) groups is reported. The method allows the construction of α-quaternary carbon centers in amides. Various mono- and disubstituted RTA-groups are applied to the arylation of primary, secondary, and tertiary α-C(sp3)?H-bonds. These radical transformations proceed in good to excellent yields and the cascades comprise a 1,6-hydrogen atom transfer, followed by a 1,4-aryl migration with subsequent SO2 extrusion.

Mutual kinetic resolution of 3-methyl-3,4-dihydro-2H-1,4-benzoxazines and 2-alkoxyacyl chlorides

[Figure not available: see fulltext.] Stereoselective acylation of racemic 3-methyl-3,4-dihydro-2Н-1,4-benzoxazine and its 7,8-difluoro-substituted analog with racemic 2-alkoxyacyl chlorides was stidied. The reactions of 3-methyl-3,4-dihydro-2H-1,4-benzoxazines with 2-methoxyisopentanoyl chloride were found to be more selective (selectivity factor s 31–32) compared to the acylation with other studied propanoyl chlorides (s 18–21). This fact was probably caused by the significant steric hindrance due to the isopropyl substituent in acyl chloride compared to the methyl group in reagents derived from propanoic acid.

C3-Symmetric Tricyclo[2.2.1.02,6]heptane-3,5,7-triol

A straightforward access to a hitherto unknown C3-symmetric tricyclic triol both in racemic and enantiopure forms has been developed. Treatment of 7-tert-butoxynorbornadiene with peroxycarboxylic acids provided mixtures of C1- and C3-symmetric 3,5,7-triacyloxynortricyclenes via transannular π-cyclization and replacement of the tert-butoxy group. By refluxing in formic acid, the C1-symmetric esters were converted to the C3-symmetric formate. Hydrolysis gave diastereoisomeric triols, which were separated by recrystallization. Enantiomer resolution via diastereoisomeric tri(O-methylmandelates) delivered the target triols on a gram scale. The pure enantiomers are useful as core units of dopants for liquid crystals.

Asymmetric Hydrogenation of Isoxazolium Triflates with a Chiral Iridium Catalyst

The iridium catalyst [IrCl(cod)]2–phosphine–I2(cod=1,5-cyclooctadiene) selectively reduced isoxazolium triflates to isoxazolines or isoxazolidines in the presence of H2. The iridium-catalyzed hydrogenation proceeded in high-to-good enantioselectivity when an optically active phosphine–oxazoline ligand was used. The 3-substituted 5-arylisoxazolium salts were transformed into 4-isoxazolines with up to 95:5 enantiomeric ratio (e.r.). Chiral cis-isoxazolidines were obtained in up to 89:11 e.r., with no formation of their trans isomers, when the substrates had a primary alkyl substituent at the 5-position. The mechanistic studies indicate that the hydridoiridium(III) species prefers to deliver its hydride to the C5 atom of the isoxazole ring. The hydride attack leads to the formation of the chiral isoxazolidine via a 3-isoxazoline intermediate. Meanwhile, in the selective formation of 4-isoxazolines, hydride attack at the C5 atom may be obstructed by steric hindrance from the 5-aryl substituent.

CHIRAL DOPANTS HAVING A NORTRICYCLAN UNIT

The present invention relates to chiral dopants having a nortricyclan unit of the general formula (I) in which P1-P3 are organic groups as defined in Claim 1, to the use thereof as components in liquid-crystalline mixtures, and to liquid-crystal and elect

The determination of the absolute configuration of a chiral 2,3′-diindolylarylmethane by NMR spectroscopy

The University of Chinese Academy of Sciences, Beijing 100864, China We present the determination of the absolute configuration of a chiral 2,3′-diindolylarylmethane 1 by using the combination of NMR spectroscopic and circular dichroism techniques. The re

NOVEL PROCESS FOR SYNTHESIS OF POLYPHENOLS

The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.

Imaging evaluation of 5HT2C agonists, [11C]WAY-163909 and [11C]vabicaserin, formed by Pictet-Spengler cyclization

The serotonin subtype 2C (5HT2C) receptor is an emerging and promising drug target to treat several disorders of the human central nervous system. In this current report, two potent and selective 5HT2C full agonists, WAY-163909 (2) a

The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing

New drugs for neglected tropical diseases such as human African trypanosomiasis (HAT) are needed, yet drug discovery efforts are not often focused on this area due to cost. Target repurposing, achieved by the matching of essential parasite enzymes to those human enzymes that have been successfully inhibited by small molecule drugs, provides an attractive means by which new drug optimization programs can be pragmatically initiated. In this report we describe our results in repurposing an established class of human Aurora kinase inhibitors, typified by danusertib (1), which we have observed to be an inhibitor of trypanosomal Aurora kinase 1 (TbAUK1) and effective in parasite killing in vitro. Informed by homology modeling and docking, a series of analogs of 1 were prepared that explored the scope of the chemotype and provided a nearly 25-fold improvement in cellular selectivity for parasite cells over human cells.

Bicunningines A and B, two new dimeric diterpenes from Cunninghamia Lanceolata

Two unprecedented dimeric diterpenoids, with a 2,3-dihydrofuran ring fusing an abietane and a 4,5-seco-abietane diterpene, were isolated from Cunninghamia lanceolata. Their structures were elucidated by spectroscopic measurements, and their absolute confi