55150-60-2Relevant academic research and scientific papers
Rhodium(III)-Catalyzed C-H Activation: Ligand-Controlled Regioselective Synthesis of 4-Methyl-Substituted Dihydroisoquinolones
Barber, Joyann S.,Scales, Stephanie,Tran-Dubé, Michelle,Wang, Fen,Sach, Neal W.,Bernier, Louise,Collins, Michael R.,Zhu, Jinjiang,McAlpine, Indrawan J.,Patman, Ryan L.
supporting information, p. 5689 - 5693 (2019/08/01)
Rh-catalyzed C-H functionalization of O-pivaloyl benzhydroxamic acids with propene gas provides access to 4-methyl-substituted dihydroisoquinolones. Good to excellent levels of regioselectivity are achieved using [CptRhCl2]2 as a precatalyst under optimized conditions. Thorough examination of aryl/heteroaryl O-pivaloyl hydroxamic acid substrates, ligand effects on C-H site selectivity, alkene scope, and demonstration of scale are discussed within.
Ligand design for Rh(iii)-catalyzed C-H activation: An unsymmetrical cyclopentadienyl group enables a regioselective synthesis of dihydroisoquinolones
Hyster, Todd K.,Dalton, Derek M.,Rovis, Tomislav
, p. 254 - 258 (2015/02/05)
We report the regioselective synthesis of dihydroisoquinolones from aliphatic alkenes and O-pivaloyl benzhydroxamic acids mediated by a Rh(iii) precatalyst bearing sterically bulky substituents. While the prototypical Cp ligand provides product with low s
Pharmaceutical composition containing 1-(imidazole-1-yl)-isoquinolines and method of treating hyperlipemia
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, (2008/06/13)
This application discloses pharmaceutical compositions containing, and a method of treatment with, 1-(1-imidazolyl)-isoquinolines of the general formula I and their physiologically tolerated salts, SPC1In which R 1, R 2 and R 3 represent hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, R 1, R 2 and R 3 may be identical or different, R 4 represents hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or chlorine, and R 5 represents hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, phenyl or chlorine.
