55153-18-9Relevant academic research and scientific papers
Palladium-Catalyzed Chemo- and Enantioselective C?O Bond Cleavage of α-Acyloxy Ketones by Hydrogenolysis
Chen, Jianzhong,Zhang, Zhenfeng,Liu, Delong,Zhang, Wanbin
supporting information, p. 8444 - 8447 (2016/07/19)
A chemoselective C?O bond cleavage of the ester alkyl side-chain of α-acyloxy ketones was realized for the first time by a highly efficient palladium-catalyzed hydrogenolysis (S/C=6000, the highest catalytic efficiency by far). Furthermore, a kinetic resolution of α-acyloxy ketones was first developed by enantioselective hydrogenolysis with good yields and up to 99 % ee.
Palladium-catalyzed asymmetric hydrogenation of α-acyloxy-1- arylethanones
Chen, Jianzhong,Liu, Delong,Butt, Nicholas,Li, Chao,Fan, Dongyang,Liu, Yangang,Zhang, Wanbin
, p. 11632 - 11636 (2013/11/06)
First hand: The first example of a palladium-catalyzed asymmetric hydrogenation of α-acyloxy ketones (1) was accomplished to give the hydrogenated products 2 with by far the highest catalytic efficiency in up to quantitative conversions and excellent enantioselectivities. The hydrogenated products could serve as important intermediates for the preparation of many drug candidates. TFE=2,2,2-trifluoroethanol. Copyright
Synthesis of Some 4-Phenylisocoumarins
Sarkhel, B. K.,Srivastava, Jagdish N.
, p. 158 - 159 (2007/10/02)
Appropriately substituted benzoic acids (Ia-Ij) on treatment under reflux with 1-bromoacetophenone and potassium carbonate in the presence of very small quantity of water yield the corresponding benzoylmethyl benzoates (IIa-j), which undergo cyclization w
