55178-75-1

Basic information

• Product Name: (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 55178-75-1
• Molecular Weight: 283.37
• Mol File: 55178-75-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(55178-75-1)
• EPA Substance Registry System: (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(55178-75-1)

Safety Data

• Hazardous Substances Data: 55178-75-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 91-16-7 1,2-dimethoxybenzene 
• 88953-56-4 3-methyl-5-phenyloxazolidine 
• 16620-96-5 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 108-90-7 chlorobenzene 
• 1147090-58-1 2-(N-(3,4-dimethoxybenzyl)-N-methylamino)-1-phenylethyl N',N'-diisopropylcarbamate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 63-64-9 N-methylveratrylamine 
• 128942-54-1 2-[(3,4-Dimethoxy-benzyl)-methyl-amino]-1-phenyl-ethanone 
• 128942-60-9 2-(methyl-veratryl-amino)-1-phenyl-ethanol 

Relevant articles and documents

Nucleophilic addition of β-amino carbanions to arynes: One-pot synthesis of 4-aryl-N-methyl-1,2,3,4-tetrahydroisoquinolines

A novel approach for the direct C-4 arylation of N-methyl-1,2,3,4- tetrahydroisoquinolines by nucleophilic addition of β-aminocarbanions to benzynes is described which provides a one-pot procedure for synthesis of the title compounds.

A New Synthesis of 1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines

1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines 6 are obtained from aromatic aldehydes 1, methyl amine and α-haloacetophenones 2 in the presence of sodium borohydride followed by cyclization with sulfuric acid and zinc in methanol.