551944-29-7Relevant academic research and scientific papers
BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDES AND PROTEIN CONJUGATES THEREOF
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Paragraph 0634-0636, (2018/12/04)
Provided herein are compounds, compositions and methods for the treatment of diseases and disorders associated with the liver X receptor, including bis-octahydrophenanthrene carboxamides and protein (e.g., antibody) drug conjugates thereof.
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters
Singh, Sheo B.,Ondeyka, John G.,Liu, Weiguo,Chen, Steve,Chen, Tom S.,Li, Xiaohua,Bouffard, Aileen,Dropinski, James,Jones, A. Brian,McCormick, Sherrie,Hayes, Nancy,Wang, Jianhua,Sharma, Neelam,MacNaul, Karen,Hernandez, Melba,Chao, Yu-Sheng,Baffic, Joanne,Lam, My-Hanh,Burton, Charlotte,Sparrow, Carl P.,Menke, John G.
, p. 2824 - 2828 (2007/10/03)
Liver X receptors are nuclear receptors that regulate metabolism of cholesterol. They are activated by oxysterols resulting in increased transcription of the ABCA1 gene, promoting cholesterol efflux and HDL formation. We have identified podocarpic acid an
Therapeutic compounds for treating dyslipidemic conditions
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, (2008/06/13)
Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia ?and (b) Formula Ib are novel LXR agonists and are useful in the treatment of dyslipidemic conditions p
