551944-34-4Relevant academic research and scientific papers
BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDES AND PROTEIN CONJUGATES THEREOF
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, (2018/12/04)
Provided herein are compounds, compositions and methods for the treatment of diseases and disorders associated with the liver X receptor, including bis-octahydrophenanthrene carboxamides and protein (e.g., antibody) drug conjugates thereof.
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters
Singh, Sheo B.,Ondeyka, John G.,Liu, Weiguo,Chen, Steve,Chen, Tom S.,Li, Xiaohua,Bouffard, Aileen,Dropinski, James,Jones, A. Brian,McCormick, Sherrie,Hayes, Nancy,Wang, Jianhua,Sharma, Neelam,MacNaul, Karen,Hernandez, Melba,Chao, Yu-Sheng,Baffic, Joanne,Lam, My-Hanh,Burton, Charlotte,Sparrow, Carl P.,Menke, John G.
, p. 2824 - 2828 (2007/10/03)
Liver X receptors are nuclear receptors that regulate metabolism of cholesterol. They are activated by oxysterols resulting in increased transcription of the ABCA1 gene, promoting cholesterol efflux and HDL formation. We have identified podocarpic acid an
