55223-24-0

Upstream product

• 83-33-0 inden-1-one 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1352732-72-9 (E)-2,2'-(prop-1-ene-1,3-diyl)bis(bromobenzene) 
• 2142-69-0 2-bromophenyl methyl ketone 
• 103457-38-1 (E)-2-(2-bromobenzylidene)-2,3-dihydro-1H-inden-1-one 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 278780-91-9 3-(2-bromophenyl)-1,2-naphthoquinone 
• 278780-87-3 3-(2-bromophenyl)naphthalen-2-ol 
• 278780-85-1 2-[3-(2-bromophenyl)-2-oxopropyl]benzaldehyde 
• 278780-83-9 2-(2-bromobenzyl)-1H-indene 
• 278780-93-1 2-(2-bromophenyl)-3-hydroxy-1,4-naphthoquinone 
• 479-11-8 benzo[b]naphtho[2,3-d]furan-6,11-dione 
• 243-42-5 β-brazan 

Relevant academic research and scientific papers

Iridium-catalyzed chemoselective transfer hydrogenation of α, β-unsaturated ketones to saturated ketones in water

A chemoselective iridium-catalyzed transfer hydrogenation of α, β-unsaturated ketones was realized in water. The C[dbnd]C double bonds of 2-benzylidene indanones and analogues were hydrogenated exclusively catalyzed by an iridium complex (0.1 mol%) bearin

Enantioselective α-Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β′-Diketones

We herein describe the first enantioselective α-carbonylative arylation, providing a diverse set of chiral spiro β,β′-diketones bearing various ring sizes and functionalities in high yields and good to excellent enantioselectivities. Calculations suggest the transformation proceeds through reductive elimination instead of nucleophilic addition pathway.

PYRIDOPYRAZINE AND PYRIDOTRIAZINE INHIBITORS OF INFLUENZA VIRUS REPLICATION

Provided herein are compounds that can inhibit the replication of influenza viruses, reduce the amount of influenza viruses, and/or treat influenza. (I)

New '2-phenylnaphthalene'-mediated synthesis of benzo[b]naphtho[2,3-d] furan-6,11-diones and 6-oxa-benzo[a]anthracene-5,7,12-triones: First total synthesis of 6-oxa-benzo[a]anthracen-5-ones

We describe here a novel synthesis of benzo[b]naphtho[2,3-d]furan-6,11- diones based on the heteroannulation of 2-(2-bromophenyl)-3-hydroxy-1,4- naphthoquinones. The naphthoquinones were prepared from 3-(2-bromophenyl) naphthalen-2-ols, which were obtained by intramolecular aldol condensation of 2-[3-(2-bromophenyl)-2-oxo-propyl]benzaldehydes. Alternatively, benzo[b]naphtho[2,3-d]furan-6,11-diones were obtained more directly and efficiently by cyclization of 3-(2-bromophenyl)naphthalen-2-ols to benzo[b]naphtho[2,3-d]furans and oxidation of the resulting compounds. Furthermore, the first 6-oxabenzo[a]anthracen-5-one described was similarly obtained from 2-[3-(2-formylphenyl)-2-oxopropyl]benzoic acid and oxidized to 6-oxa-benzo[a]anthracene-5,7,12-trione.

Radical cyclisation onto nitriles

Iminyl radicals, generated by 5-exo cyclisation of alkyl, vinyl and aryl C-centred radicals onto nitriles, undergo β-scission (nitrile translocation), reduction or tandem cyclisation onto alkenes depending on the nature of the α-substituent. 5-exo Cyclisations of aryl radicals onto nitriles undergo nitrile translocation when the α-substituent is CN, CO2R, SO2Ph or CONMe2. The rate of translocation is faster than 5- or 6-exo cyclisation onto alkenes or 1,5-hydrogen abstraction of allylic hydrogens. When the α-substituents are alkyl, the intermediate iminyl radicals do not undergo nitrile translocation. (C) 2000 Elsevier Science Ltd.

1,2- and 1,4-naphthoquinones: General synthesis of benzo[b]naphtho [2,3- d]furan-6,11-diones

A new general synthesis of benzo[b]naphtho[2,3-d]furan-6,11-diones starting from readily available 2-(2'-oxo-3'-phenylpropyl)benzaldehydes is described. (C) 2000 Elsevier Science Ltd.