55239-81-1Relevant academic research and scientific papers
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists
Prat, Maria,Buil, María Antonia,Fernández, Maria Dolors,Castro, Jordi,Monleón, Juan Manuel,Tort, Laia,Casals, Gaspar,Ferrer, Manuel,Huerta, Josep Maria,Espinosa, Snia,López, Manuel,Segarra, Victor,Gavald, Amadeu,Miralpeix, Montserrat,Ramos, Israel,Vilella, Dolors,González, Marisa,Córdoba, Mnica,Cárdenas, Alvaro,Antón, Francisca,Beleta, Jorge,Ryder, Hamish
, p. 3457 - 3461 (2011/06/24)
Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.
N,N-DIACYLPIPERAZINES
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, (2008/06/13)
Diacylpiperazines of general structural formula: STR1 are: angiotensin II (A-II) antagonists with affinity for both AT 1 and AT. sub.2 receptors useful in the treatment of hypertension, congestive heat failure, cerebrovascular, cognitive, and CNS disorders.
N,N-diacylpiperazines
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, (2008/06/13)
Diacylpiperazines of general structure STR1 are: angiotensin II (A-II) antagonists selective for the type 2 (AT 2) subtype useful in the treatment of cerebrovascular, cognitive, and CNS disorders; tachykinin receptor antagonists useful in the treatment of inflammatory diseases and pain or migraine; and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
