55246-61-2Relevant articles and documents
Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)?H Carbamoylation
Dailler, David,Rocaboy, Ronan,Baudoin, Olivier
supporting information, p. 7218 - 7222 (2017/06/13)
A general and user-friendly synthesis of β-lactams is reported that makes use of Pd0-catalyzed carbamoylation of C(sp3)?H bonds, and operates under stoichiometric carbon monoxide in a two-chamber reactor. This reaction is compatible with a range of primary, secondary and activated tertiary C?H bonds, in contrast to previous methods based on C(sp3)?H activation. In addition, the feasibility of an enantioselective version using a chiral phosphonite ligand is demonstrated. Finally, this method can be employed to synthesize valuable enantiopure free β-lactams and β-amino acids.