55272-36-1

Upstream product

• 14898-67-0 ruthenium trichloride hydrate 
• 96-38-8 methylcyclopentadiene 
• 96-39-9 methylcyclopentadiene 
• 603-35-0 triphenylphosphine 
• 63767-78-2 ruthenium trichloride 

Downstream Products

• 110077-75-3 {MeCpRu(PPh3)2}2(μ-S2){BF4}2 
• 139584-18-2 {(MeCp)Ru(PPh3)}2(μ-η1,η2-Se2)2(OTf)2 
• 107604-45-5 Ru(CH₃C₅H₄)(S₂COCH₃)(P(C₆H₅)3) 

Relevant academic research and scientific papers

Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells

Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η5-MeCp)(PPh3)2Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1ˉ. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η5-MeCp)(PPh3)(L1)][CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.

Syntheses, crystal structures and MMCT properties of cyanide-bridged binuclear Ru–Fe complexes

In this report, two new binuclear mixed-valence (MV) compounds and their one-electron oxidation products, [MeCpLRu(μ-CN)Fe(dppe)Cp][PF6]n (L = dppe, (PPh3)2) (n = 1, 2), were synthesized and thoroughly characterized by single-crystal X-ray diffraction analysis. Complexes 12+ and 22+ are one-electron oxidation products of 11+ and 2+, respectively. The electronic absorption results indicate that there exists metal to metal charge transfer (MMCT) in the one-electron oxidation products, which is strongly supported by the theoretical calculations. Complexes 12+ and 22+ can be defined as Class II MV compounds. It is found that the MMCT band is obviously red-shifted on going from 12+ to 22+, because the donating electron ability of (PPh3)2 is stronger than that of dppe.

Tandem transfer hydrogenation-epoxidation of ketone substrates catalysed by alkene-tethered Ru(ii)-NHC complexes

A series of nine cyclopentadienyl Ru(ii)-NHC complexes (1-9) have been synthesised by systematically varying the ligand and/or ligand substituents: η5-C5H4R′ (R′ = H, Me), EPh3 (E = P, As), NHC (Im, BIm), where NHC = Im(R)(R′) (R, R′ = Me, Bn, 4-NO2Bn, C2H4Ph, C4H7). Each of the Ru(ii)-NHC complexes features an N-alkenyl tether to attain bidentate NHC ligands. All complexes found application as catalysts in the tandem transfer hydrogenation and epoxidation reactions of carbonyl substrates. The catalytic activity of the complexes was shown to be similar, with efficiencies of up to 69% conversion after 18 hours and varying alcohol:epoxide selectivity for a variety of electronically diverse carbonyl substrates. Complex 3, with a nitro-containing substituent on the NHC ligand, was the only complex that showed preference for the alcohol product over the epoxide after 18 hours of reaction time.

SUBSTITUTED CYCLOPENTADIENYLRUTHENIUM COMPLEXES CONTAINING (S,S) DONOR LIGANDS

The complexes Ru(η-RC5H4)Cl(PPh3)2 (R = H, CH3, CH3CO) have been shown to react with the anionic S-S donor ligands M1S2CX, (M1 = Na, K, NH4+; X = OR', NR''2, CN) to give cyclopentadienyl dithiolate complexes of ruthenium(II).Analogous compounds have been obtained from thallium cyclopentadienide and Ru(S2CX)2(PPh3)2.Ru(η-CH3COC5H4)Cl(PPh3)2 (III) has been made by reaction between acetylcyclopentadiene, RuCl3(aq.), and PPh3 in absolute ethanol.Complexes of formula Ru(η-RC5H4)(S2CX)(PPh3)2, with the dithiolate ligand monodentate, are obtained when R = H, X = OC6H11; R = CH3, X = OCH3; R = H, CH3, X = CN.In the other cases studied the isolated complexes contain a bidentate S-S ligand.Steric effects as well as the electronic properties of dithiolate ligands, seem to influence the choice between the two coordination modes.Reaction of III with NaS2CNEt2 affords Ru(S2CNEt2)2(PPh3)2 as the sole product.Carbonylation of complex VI, Ru(η-C5H5)(S2COC6H11)(PPh3)2 takes place in solution, but the carbonyl complex could not be isolated.