55277-90-2

Upstream product

• 2637-34-5 2-Sulfanylpyridine 
• 75-44-5 phosgene 
• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 

Downstream Products

• 220235-77-8 4-methoxybenzyl-2-pyridylthio carbonate 
• 310890-40-5 [4(S)-azido-3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S)-ylmethoxy]-tert-butyl-diphenyl-silane 
• 310890-42-7 [4(S)-azido-3(S)-isobutyl-5(R)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S)-ylmethoxy]-tert-butyl-diphenyl-silane 
• 438216-13-8 2-O-benzoyl-4,6-O-benzylidene-3-O-[(S)-1-(methoxycarbonyl)-2-cyclohexylethyloxy]-β-D-galactopyranosyl 2-thiopyridyl carbonate 
• 1187746-80-0 3-O-acetyl-2,4-di-O-benzyl-α,β-D-xylopyranose 2-thiopyridyl carbonate 
• 233674-87-8 2,3,4,6-Tetra-O-benzoyl-β-D-galactopyranosyl S-(2-pyridyl) thiocarbonate 
• 225220-01-9 (2S,2aS,2bR,4R,5aR,6S)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2b-methyl-1-oxo-5a-phenylsulfanyl-4-(pyridin-2-ylsulfanylcarbonyloxy)-octahydro-3-oxa-6a-aza-cyclobuta[a]pentalene-6-carboxylic acid benzyl ester 
• 160776-15-8 2,3,4-tri-O-benzyl-β-L-fucopyranosyl 2-thiopyridyl carbonate 

Relevant academic research and scientific papers

Synthesis of a potent antagonist of E-selectin.

A synthesis of an antagonist of E-selectin previously reported by a group at Novartis Pharma in Basel is described. An important feature involves the formation of an ether linkage based on a Rh(II)-catalyzed reaction. Stereocontrolled glycosylations rely on the anomeric activation of 2-pyridylthio carbonate as leaving group for the attachment of beta-D-galactopyranosyl and alpha-L-fucopyranosyl units on a common 1,5-anhydro D-glucitol scaffold.

New Amino-protective Reagents for t-Butoxycarbonylation and Benzyloxycarbonylation of Amines and Amino Acids

New amino-protective reagents for t-butoxycarbonylation and benzyloxycarbonylation of amines and amino acids have been developed. t-Butyl 2-pyridyl carbonate and t-butyl S-(2-pyridyl) thiocarbonate react cleanly with various amines and amino acids to afford N-Boc amines and N-Boc amino acids in high yields.Benzyl 2-pyridyl carbonate and O-benzyl S-(2-pyridyl) thiocarbonate are also found to be very effective in the benzyloxycarbonylation of amino acids.