552849-33-9

Usage

Uses

Used in Organic Synthesis:
cis-3-Hydroxycyclobutanecarboxylic acid serves as a versatile building block in organic synthesis, facilitating the creation of a wide array of biologically active molecules. Its unique structural properties and reactivity make it an essential component in the synthesis of complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, cis-3-Hydroxycyclobutanecarboxylic acid is utilized for the development of new drugs and therapeutic agents. Its potential applications in medicine are attributed to its ability to form the backbone of various pharmaceutically relevant molecules, contributing to the advancement of novel treatments and therapies.
Used in Materials Science:
cis-3-Hydroxycyclobutanecarboxylic acid also finds application in materials science, where it is employed in the development of novel materials with specific properties. Its unique structure allows for the engineering of materials with tailored characteristics, such as enhanced stability, reactivity, or selectivity, which can be beneficial in various applications.
Used in Polymer Chemistry:
In the field of polymer chemistry, cis-3-Hydroxycyclobutanecarboxylic acid is used to develop new types of polymers with distinct properties. Its incorporation into polymer structures can lead to materials with improved mechanical strength, thermal stability, or chemical resistance, making them suitable for specialized applications in various industries.

InChI:InChI=1/C5H8O3/c6-4-1-3(2-4)5(7)8/h3-4,6H,1-2H2,(H,7,8)/t3-,4+

Upstream product

• 695-95-4 methyl 3-oxocyclobutanecarboxylate 
• 4934-99-0 methylester of 3-hydroxycyclobutane-1-carboxylic acid 
• 480449-99-8 3-hydroxycyclobutylcarboxylic acid benzyl ester 

Downstream Products

• 1089340-69-1 3-hydroxy-N-methylcyclobutanecarboxamide 

Relevant academic research and scientific papers

Method for synthesizing trans-3-hydroxy cyclobutyl formic acid

The invention belongs to the field of organic synthesis and discloses a method for synthesizing trans-3-hydroxy cyclobutyl formic acid. The method comprises the following steps: by using an appropriate reducing agent, reducing 3-carbonyl-cyclobutane formate (C1-C6 alkyl ester) into single trans-3-hydroxy cyclobutyl formic ether in an efficient stereoselectivity manner, and further performing a Mitsunobu reaction and hydrolysis, thereby obtaining single trans-3-hydroxy cyclobutyl formic acid. The method provided by the invention is high in synthesis method raw material availability, mild in reaction condition, good in stereoselectivity and relatively high in yield; in addition, aftertreatment and purification are both easy to operate, and the method is applicable to industrial amplified production.

Synthesis method of cis-3-hydroxycyclobutylcarboxylic acid

The invention belongs to the field of organic synthesis, and discloses a synthesis method of cis-3-hydroxycyclobutylcarboxylic acid. The synthesis method comprises the following steps: performing efficient stereoselective reduction on 3-carbonyl-cyclobutanecarboxylate (C1-C6 alkyl ester) into single cis-3-hydroxy-cyclobutanecarboxylate by using a proper reducing agent, and performing a hydrolysisreaction to finally obtain the single cis-3-hydroxy-cyclobutanecarboxylic acid. By the synthesis method, raw materials are easy to obtain, the reaction condition is mild, the stereoselectivity is good, and the yield is relatively high; in addition, post-treatment and purification are easy to operate, and the synthesis method is suitable for industrial scale-up production.

DIAMINE DERIVATIVES

A compound represented by formula (1):Q1-Q2-To-N(R1) -Q3-N(R2)-T1-Q4 [wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group: (wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

DIAMINE DERIVATIVES

A compound represented by the general formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.