552885-78-6

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-[[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl](4-fluorophenyl)acetyl]- , phenylmethyl ester
• CAS NO: 552885-78-6
• Molecular Formula: C30H38FN3O5
• Molecular Weight: 539.647
• Mol File: 552885-78-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-[[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl](4-fluorophenyl)acetyl]- , phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-[[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl](4-fluorophenyl)acetyl]- , phenylmethyl ester(552885-78-6)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-[[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl](4-fluorophenyl)acetyl]- , phenylmethyl ester(552885-78-6)

Safety Data

• Hazardous Substances Data: 552885-78-6(Hazardous Substances Data)

Upstream product

• 552885-77-5 (+/-)-[1-(tert-butoxycarbonyl)piperidin-4-yl](4-fluorophenyl)acetic acid 
• 31166-44-6 phenylmethyl 1-piperazinecarboxylate 
• 405-50-5 p-Fluorophenylacetic acid 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 385844-14-4 (+/-)-[1-(tert-butoxycarbonyl)-4-hydroxypiperidin-4-yl](4-fluorophenyl)acetic acid 
• 385844-15-5 [1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl](4-fluorophenyl)acetic acid 

Downstream Products

• 929268-72-4 3-(3'-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-68-8 3-(3-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-70-2 3-(2'-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-66-6 3-(5-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-67-7 3-(4-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-65-5 3-(6-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-74-6 1-[3-(4'-fluorobiphenyl-2-yl)propanoyl]-4-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]piperazine 
• 838819-92-4 3-biphenyl-2-yl-1-[4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)acetyl]piperazin-1-yl]propane-1-one 
• 707542-35-6 1-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]-4-(3-biphenyl-2-ylpropyl)piperazine 
• 552885-79-7 benzyl 4-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]piperazine-1-carboxylate 
• 552885-80-0 1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]piperazine 
• 942037-60-7 benzyl 4-[(4-fluorophenyl)(piperidin-4-yl)acetyl]piperazine-1-carboxylate 

Relevant articles and documents

Novel piperazines: Potent melanocortin-4 receptor antagonists with anxiolytic-like activity

In the present study, we found that a novel piperazine compound, 11a, showed a moderate affinity (IC50 = 333 nM) for the MC4 receptor. We developed the new type of piperazine compounds and found that mono-piperazine 11b exhibited a high-affinity (IC50 = 40.3 nM) for the MC4 receptor. We also found that a series of biphenyl analogues exhibited a high-affinity for the receptor, and in particular, compound 11j exhibited the highest affinity for the MC4 receptor with an IC50 value of 14.5 nM. Furthermore, some of these compounds, when administered orally, significantly reversed the stress-induced anxiety-like behavior in rats. In this paper, we report the synthesis, structure-activity relationships, and oral activity of the novel mono-piperazines as MC4 receptor antagonists.