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929268-67-7

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  • 929268-67-7 Structure

  • Basic information

    1. Product Name: 3-(4-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one
    2. Synonyms:
    3. CAS NO:929268-67-7
    4. Molecular Formula:
    5. Molecular Weight: 573.726
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 929268-67-7.mol
    9. Article Data: 1

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(4-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(4-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one(929268-67-7)
    11. EPA Substance Registry System: 3-(4-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one(929268-67-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 929268-67-7(Hazardous Substances Data)

929268-67-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 929268-67-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,2,6 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 929268-67:
(8*9)+(7*2)+(6*9)+(5*2)+(4*6)+(3*8)+(2*6)+(1*7)=217
217 % 10 = 7
So 929268-67-7 is a valid CAS Registry Number.

929268-67-7Downstream Products

929268-67-7Relevant articles and documents

Novel piperazines: Potent melanocortin-4 receptor antagonists with anxiolytic-like activity

Nozawa, Dai,Okubo, Taketoshi,Ishii, Takaaki,Takamori, Kazuaki,Chaki, Shigeyuki,Okuyama, Shigeru,Nakazato, Atsuro

, p. 2375 - 2385 (2007/10/03)

In the present study, we found that a novel piperazine compound, 11a, showed a moderate affinity (IC50 = 333 nM) for the MC4 receptor. We developed the new type of piperazine compounds and found that mono-piperazine 11b exhibited a high-affinity (IC50 = 40.3 nM) for the MC4 receptor. We also found that a series of biphenyl analogues exhibited a high-affinity for the receptor, and in particular, compound 11j exhibited the highest affinity for the MC4 receptor with an IC50 value of 14.5 nM. Furthermore, some of these compounds, when administered orally, significantly reversed the stress-induced anxiety-like behavior in rats. In this paper, we report the synthesis, structure-activity relationships, and oral activity of the novel mono-piperazines as MC4 receptor antagonists.

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