5529-94-2Relevant academic research and scientific papers
Anthranilic acid hydrazide in the synthesis of fused polycyclic compounds with quinazoline moieties
Ukhin,Kuz'Mina,Gribanov,Belousova,Orlova
, p. 2340 - 2348 (2008)
A modified procedure was developed for the synthesis of 5,6,7,8,13,13a-hexahydrophthalazino[1,2-b]quinazoline-5,8-dione and 6-amino-5,6,6a,11-tetrahydroisoindolo[2,1-a]quinazoline-5,11-dione from o-formylbenzoic acid and anthranilic acid hydrazide. The mechanism of the transformation is suggested, some reactions were studied, and new derivatives of these compounds were synthesized. Anthranilic acid hydrazide was used in the novel synthesis of 5-substituted phthalazino[1,2-b]quinazolin-8-one derivatives. The possible reaction mechanism is discussed. 5,6,7,8-Tetrahydrophthalazino[1, 2-b]quinazoline-5,8-dione and 5-phenylphthalazino[2,1-b]quinazolin-8-one were studied by X-ray diffraction.
Synthesis and biological activity of 5-substituted 8-oxo-8H-phthalazinoquinazolines
Razvi, Mehboob,Ramalingam, T,Sattur, P B
, p. 399 - 400 (2007/10/02)
Several 5-substituted 8-oxo-8H-phthalazinoquinazolines (3) have been synthesised by the reaction of 4-substituted 1-chlorophthalazines (1) with anthranilic acid (2).These compounds have been screened for their antiinflammatory, antihypertensive and motor activities.Few compounds exhibit markled antiinflammatory activity.
